The Journal of Thoracic and Cardiovascular Surgery
Volume 135, Issue 6 , Pages 1228-1236 , June 2008

En bloc esophagectomy reduces local recurrence and improves survival compared with transhiatal resection after neoadjuvant therapy for esophageal adenocarcinoma

  • C. Rizzetto, MD

      Affiliations

    • Department of Surgery, the Keck School of Medicine, University of Southern California, Los Angeles, Calif
    • ,
  • S.R. DeMeester, MD

      Affiliations

    • Department of Cardiothoracic Surgery, the Keck School of Medicine, University of Southern California, Los Angeles, Calif
    • Corresponding Author InformationAddress for reprints: Steven R. DeMeester, MD, Department of Cardiothoracic Surgery, University of Southern California, 1510 San Pablo St, Suite 514, Los Angeles, CA 90033.
    • ,
  • J.A. Hagen, MD

      Affiliations

    • Department of Surgery, the Keck School of Medicine, University of Southern California, Los Angeles, Calif
    • ,
  • C.G. Peyre, MD

      Affiliations

    • Department of Surgery, the Keck School of Medicine, University of Southern California, Los Angeles, Calif
    • ,
  • J.C. Lipham, MD

      Affiliations

    • Department of Surgery, the Keck School of Medicine, University of Southern California, Los Angeles, Calif
    • ,
  • T.R. DeMeester, MD

      Affiliations

    • Department of Surgery, the Keck School of Medicine, University of Southern California, Los Angeles, Calif

Received 2 July 2007 ,Revised 15 September 2007 ,Accepted 4 October 2007.

References 

  1. Pohl H, Welch HG. The role of overdiagnosis and reclassification in the marked increase of esophageal adenocarcinoma incidence. J Natl Cancer Inst. 2005;97:142–146
  2. DeMeester SR. Adenocarcinoma of the esophagus and cardia: a review of the disease and its treatment. Ann Surg Oncol. 2006;13:12–30
  3. Hagen JA, DeMeester SR, Peters JH, et al. Curative resection for esophageal adenocarcinoma: analysis of 100 en bloc esophagectomies. Ann Surg. 2001;234:520–531
  4. Hagen JA, Peters JH, DeMeester TR. Superiority of extended en bloc esophagogastrectomy for carcinoma of the lower esophagus and cardia. J Thorac Cardiovasc Surg. 1993;106:850–859
  5. Orringer MB. Transhiatal esophagectomy without thoracotomy for carcinoma of the thoracic esophagus. Ann Surg. 1984;200:282–288
  6. Rouvelas I, Zeng W, Lindblad M, Viklund P, Ye W, Lagergren J. Survival after neoadjuvant therapy compared with surgery alone for resectable esophageal cancer in a population-based study. World J Surg. 2006;30:2182–2190
  7. Walsh TN, Noonan N, Hollywood D, et al. A comparison of multimodal therapy and surgery for esophageal adenocarcinoma. [erratum appears in N Engl J Med. 1999;341:384] N Engl J Med. 1996;335:462–467
  8. Walsh T. Correction to “A comparison of multimodal therapy and surgery for esophageal adenocarcinoma.”. N Engl J Med. 1999;341:384
  9. Group MRCMUGTC. Medical Research Council (MRC) randomised phase III trial of surgery with or without pre-operative chemotherapy in resectable cancer of the oesophagus. [abstract] Br J Cancer. 2000;83(suppl 1):1
  10. Kelsen DP, Ginsberg R, Pajak TF, et al. Chemotherapy followed by surgery compared with surgery alone for localized esophageal cancer. N Engl J Med. 1998;339:1979–1984
  11. Urba S, Orringer M, Turisi A, et al. Randomized trial of preoperative chemoradiation versus surgery alone in patients with locoregional esophageal carcinoma. J Clin Oncol. 2001;19:305–313
  12. Reynolds JV, Muldoon C, Hollywood D, et al. Long-term outcomes following neoadjuvant chemoradiotherapy for esophageal cancer. Ann Surg. 2007;245:707–716
  13. Rice TW, Blackstone EH, Adelstein DJ, et al. Role of clinically determined depth of tumor invasion in the treatment of esophageal carcinoma. J Thorac Cardiovasc Surg. 2003;125:1091–1102
  14. Hagen J, DeMeester S, Peters J, et al. Curative resection for esophageal adenocarcinoma: analysis of 100 en bloc esophagectomies. Ann Surg. 2001;234:520–531
  15. Portale G, Hagen JA, Peters JH, et al. Modern 5-year survival of resectable esophageal adenocarcinoma: single institution experience with 263 patients. J Am Coll Surg. 2006;202:588–598
  16. Altorki NK, Girardi L, Skinner DB. En bloc esophagectomy improves survival for stage III esophageal cancer. J Thorac Cardiovasc Surg. 1997;114:948–956
  17. Lerut T, Coosemans W, Decker G, et al. Extended surgery for cancer of the esophagus and gastroesophageal junction. J Surg Res. 2004;117:58–63
  18. Johansson J, DeMeester TR, Hagen JA, et al. En bloc vs transhiatal esophagectomy for stage T3 N1 adenocarcinoma of the distal esophagus. Arch Surg. 2004;139:627–633
  19. Smith DD, Schwarz RR, Schwarz RE. Impact of total lymph node count on staging and survival after gastrectomy for gastric cancer: data from a large US-population database. J Clin Oncol. 2005;23:7114–7124
  20. Prenzel K, Konig A, Schneider P. Reduced incidence of nodal micrometastases after major response to neoadjuvant chemoradiation in locally advanced esophageal cancer. Ann Surg Oncol. 2007;14:954–959
  21. Hulscher JB, van Sandick JW, Tijssen JG, et al. The recurrence pattern of esophageal carcinoma after transhiatal resection. J Am Coll Surg. 2000;191:143–148
  22. van Sandick JW, van Lanschot JJB, Ten Kate FJ, et al. Indicators of prognosis after transhiatal esophageal resection without thoracotomy for cancer. J Am Coll Surg. 2002;194:28–36

 Read at the Thirty-third Annual Meeting of the Western Thoracic Surgical Association, Sanata Ana Pueblo, NM, June 27–30, 2007.

PII: S0022-5223(08)00216-X

doi: 10.1016/j.jtcvs.2007.10.082

The Journal of Thoracic and Cardiovascular Surgery
Volume 135, Issue 6 , Pages 1228-1236 , June 2008

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