The Journal of Thoracic and Cardiovascular Surgery
Volume 135, Issue 3 , Pages 492-494 , March 2008

Aprotinin and Cardiac Surgery

  • Abe DeAnda Jr., MD

      Affiliations

    • Corresponding Author InformationAddress for reprints: Abe DeAnda Jr, Montefiore Medical Center/Albert Einstein College of Medicine, Department of Cardiovascular and Thoracic Surgery, Montefiore Medical Park, 1575 Blondell Avenue Suite 125, Bronx, NY 10461.

Received 16 November 2007 ,Accepted 7 December 2007.

References 

  1. Cosgrove DM, Heric B, Lytle BW, Taylor PC, Novoa R, Golding LA, et al. Aprotinin therapy for reoperative myocardial revascularization: a placebo-controlled study. Ann Thorac Surg. 1992;54:1031–1036
  2. Mangano DT, Tudor IC, Dietzel C. The risk associated with aprotinin in cardiac surgery. N Engl J Med. 2006;354:353–365
  3. Karkouti K, Beattie WS, Dattilo KM, McCluskey SA, Ghannam M, Hamdy A, et al. A propensity score case-control comparison of aprotinin and tranexamic acid in high-transfusion-risk cardiac surgery. Transfusion. 2006;46:327–338
  4. Mangano DT, Miao Y, Vuylsteke A, Tudor IC, Juneja R, Filipescu D, et al. Mortality associated with aprotinin during 5 years following coronary artery bypass graft surgery. JAMA. 2007;297:471–479
  5. Pagano D, Howell NJ, Freemantle N, Cunningham D, Bonser RS, Graham TR, et al. Bleeding in cardiac surgery: the use of aprotinin does not affect survival. J Thorac Cardiovasc Surg. 2008;135:495–502
  6. Society of Thoracic Surgeons Blood Conservation Guideline Task Force, Ferraris VA, Ferraris SP, Saha SP, Hessel EA 2nd, Haan CK, Royston BD, et al; Society of Cardiovascular Anesthesiologists Special Task Force on Blood Transfusion, Spiess BD, Shore-Lesserson L, Stafford-Smith M, Mazer CD, Bennett-Guerrero E, Hill SE, et al. Preioperative blood transfusion and blood conservation in cardiac surgery: the Society of Thoracic Surgeons and The Society of Cardiovascular Anesthesiologists clinical practice guideline. Ann Thorac Surg. 2007;83:S27–86.
  7. Koch CG, Liang L, Duncan AI, Mihaljevic T, Loop FD, Starr NJ, et al. Transfusion in coronary artery bypass grafting is associated with reduced long-term survival. Ann Thorac Surg. 2006;81:1650–1657
  8. Furnary AP, Wu Y, Hiratzka LF, Grunkemeier GL, Page US. Aprotinin does not increase the risk of renal failure in cardiac surgery patients. Circulation. 2007;116(II Suppl):I127–I133

PII: S0022-5223(08)00085-8

doi: 10.1016/j.jtcvs.2007.12.025

The Journal of Thoracic and Cardiovascular Surgery
Volume 135, Issue 3 , Pages 492-494 , March 2008

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