The Journal of Thoracic and Cardiovascular Surgery
Volume 135, Issue 5 , Pages 991-998.e2 , May 2008

Regional remodeling strain and its association with myocardial apoptosis after myocardial infarction in an ovine model

Received 30 May 2007 ,Revised 5 October 2007 ,Accepted 6 December 2007.

References 

  1. Pfeffer MA, Braunwald E. Ventricular remodeling after myocardial infarction: experimental observations and clinical implications. Circulation. 1990;81:1161–1172
  2. Jugdutt BI. Ventricular remodeling after infarction and the extracellular collagen matrix: when enough is enough?. Circulation. 2003;108:1395–1403
  3. Anversa P, Li P, Zhang X, Olivetti G, Capasso JM. Ischaemic myocardial injury and ventricular remodeling. Cardiovasc Res. 1993;27:145–157
  4. Gupta KB, Ratcliffe MB, Fallert MA, Edmunds LH, Bogen DK. Changes in passive mechanical stiffness of myocardial tissue with aneurysm formation. Circulation. 1994;89:2315–2326
  5. MacKenna DA, Dolfi F, Vuori K, Ruoslahti E. Extracellular signal-regulated kinase and c-Jun HN2-terminal kinase activation by mechanical stretch is integrin-dependent and matrix-specific in rat cardiac fibroblasts. J Clin Invest. 1998;101:301–310
  6. Fuzhong Q, Liang MC, Liang C. Progressive left ventricular remodeling, myocyte apoptosis, and protein signaling cascades after myocardial infarction in rabbits. Biochim Biophys Acta. 2005;1740:499–513
  7. Bialik S, Green DL, Sasson IE, Cheng R, Horner JW, Evans SM, et al. Myocyte apotosis during acute myocardial infarction in the mouse localizes to hypoxic regions but occurs independently of p53. J Clin Invest. 1997;100:1363–1372
  8. Takemura G, Fujiwara H. Morphological aspects of apoptosis in heart diseases. J Cell Mol Med. 2006;10:56–75
  9. Bursch W, Kliene L, Tenniswood M. The biochemistry of cell death by apoptosis. Biochem Cell Biol. 1990;68:1071–1074
  10. Tewari M, Quan LT, O'Rourke K, Desnoyers S, Zeng Z, Beidler DR, et al. Yamma/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly (ADP-ribose) polymerase. Cell. 1995;81:801–809
  11. Moissac D, Gurevich RM, Zheng H, Singal PK, Kirshenbaum LA. Caspase activation and mitochondrial cytochrome c release during hypoxia-mediated apoptosis of adult ventricular myocytes. J Mol Cell Cardiol. 2000;32:53–63
  12. Kilic A, Li T, Nolan TD, Nash JR, Li S, Prastein DJ, et al. Strain-related regional alterations of calcium-handling proteins in myocardial remodeling. J Thorac Cardiovasc Surg. 2006;132:900–908
  13. Wyatt HL, Meerbaum S, Heng MK, Gueret P, Corday E. Cross-sectional echocardiography. III. Analysis of mathematic models for quantifying volume of symmetric and asymmetric left ventricles. Am Heart J. 1980;100:821–828
  14. Condorelli G, Roncarati R, Ross J, Pisani A, Stassis G, Todaro M, et al. Heart-targeted overexpression of caspase3 in mice increases infarct size and depresses cardiac function. Proc Natl Acad Sci U S A. 2001;98:9977–9982
  15. Kharbanda S, Pandey P, Schofield L, Israels C, Roncinske R, Yoshida K, et al. Role for Bcl-xL as an inhibitor of cytosolic cytochrome C accumulation in DNA damage-induced apoptosis. Proc Natl Acad Sci U S A. 1997;94:6939–6942
  16. Abbate A, Bondi-Zoccai GGL, Bussani R, Dobrina A, Camilot D, Feroce F, et al. Increased myocardial apoptosis in patients with unfavorable left ventricular remodeling and early symptomatic post-infarction heart failure. J Am Coll Cardiol. 2003;41:753–760
  17. Baldi A, Abbate A, Bussani R, Patti G, Melfi R, Angelini A, et al. Apoptosis and post-infarction left ventricular remodeling. J Mol Cell Cardiol. 2002;34:165–174
  18. Wencker D, Chandra M, Nguyen K, Miao W, Garantziotis S, Factor SM, et al. A mechanistic role for cardiac myocyte apoptosis in heart failure. J Clin Invest. 2003;111:1497–1504
  19. Kajstura J, Cheng W, Reiss K, Clark WA, Sonneblick EH, Krajewski S, et al. Apoptotic and necrotic myocyte cell deaths are independent contributing variables of infarct size in rats. Lab Invest. 1996;74:86–107
  20. Bing OH. Hypothesis: apoptosis may be a mechanism for the transition to heart failure with chronic pressure overload. J Mol Cell Cardiol. 1994;26:943–948
  21. Ashkenazi A, Dixit VM. Death receptors: signaling and modulation. Science. 1998;281:1305–1308
  22. von Harsdorf R, Li PF, Dietz R. Signaling pathways in reactive oxygen species-induced cardiomyocyte apoptosis. Circulation. 1999;99:2934–2941
  23. Green DR, Reed JC. Mitochondria and apoptosis. Science. 1998;281:1309–1312
  24. Chiarugi A, Moskowitz MA. Cell biology: PARP-1, a perpetrator of apoptotic cell death?. Science. 2002;297:200–201
  25. Colucci WS. Molecular and cellular mechanisms of myocardial failure. Am J Cardiol. 1997;80:15–25
  26. Cheng Cheng W, Li B, Kajstura J, Li P, Wolin MS, Sonnenblick EH, et al. Stretch-induced programmed myocyte cell death. J Clin Invest. 1995;96:2247–2259
  27. Athanasuleas CL, Stanley AW, Buckberg GD, Dor V, Di Donato M, Blackstone EH, et al. Surgical anterior ventricular endocardial restoration (SAVER) in the dilated remodeled ventricle after anterior myocardial infarction. J Am Coll Cardiol. 2001;37:1199–1209
  28. Sabbah HN, Sharov VG, Gupta RC, Mishra S, Rastogi S, Undrovinas AI, et al. Reversal of chronic molecular and cellular abnormalities due to heart failure by passive mechanical ventricular containment. Circ Res. 2003;93:1095–1101
  29. Razeghi P, Myers TJ, Frazier OH, Taegtmeer H. Reverse remodeling of the failing human heart with mechanical unloading. Cardiology. 2002;98:167–174

 The study was supported in part by McGowan Charitable Fund, National Institute of Health Grant R01HL081106 and National Institutes of Health Training Grant HL0772751.

 Read at the Eighty-seventh Annual Meeting of The American Association for Thoracic Surgery, Washington, DC, May 5–9, 2007.

PII: S0022-5223(08)00043-3

doi: 10.1016/j.jtcvs.2007.12.021

The Journal of Thoracic and Cardiovascular Surgery
Volume 135, Issue 5 , Pages 991-998.e2 , May 2008

Article Tools

* Image Usage & Resolution