The Journal of Thoracic and Cardiovascular Surgery
Volume 135, Issue 5 , Pages 986-990 , May 2008

Cell therapy in ischemic settings: Fact and fiction

  • Gino Gerosa, MD

      Affiliations

    • Corresponding Author InformationAddress for reprints: Gino Gerosa, MD, University of Padova Medical School, Cardiac Surgery Unit, Cardiologic, Thoracic, and Vascular Science, Via Giustiniani 1, 35128 Padova, Italy.
    • ,
  • Chiara d'Agostino, MD

Received 6 November 2007 ,Accepted 14 December 2007.

References 

  1. Anversa P, Leri A, Rota M, Hosoda T, Bearzi C, Urbanek K, et al. Concise review: stem cells, myocardial regeneration, and methodological artifacts. Stem Cells. 2007;25:589–601
  2. Kocher AA, Schlechta B, Gasparovicova A, Wolner E, Bonaros N, Laufer G. Stem cells and cardiac regeneration. Transpl Int. 2007;20:731–746
  3. Hsieh PC, Segers VF, Davis ME, MacGillivray C, Gannon J, Molkentin JD, et al. Evidence from a genetic fate-mapping study that stem cells refresh adult mammalian cardiomyocytes after injury. Nat Med. 2007;13:970–974
  4. Menasché P, Hagège AA, Scorsin M, Pouzet B, Desnos M, Duboc D, et al. Myoblast transplantation for heart failure. Lancet. 2001;357:279–280
  5. Strauer BE, Brehm M, Zeus T, Köstering M, Hernandez A, Sorg RV, et al. Repair of infarcted myocardium by autologous intracoronary mononuclear bone marrow cell transplantation in humans. Circulation. 2002;106:1913–1918
  6. Schächinger V, Assmus B, Britten MB, Honold J, Lehmann R, Teupe C, et al. Transplantation of progenitor cells and regeneration enhancement in acute myocardial infarction: final one-year results of the TOPCARE-AMI Trial. J Am Coll Cardiol. 2004;44:1690–1699
  7. Chen SL, Fang WW, Ye F, Liu YH, Qian J, Shan SJ, et al. Effect on left ventricular function of intracoronary transplantation of autologous bone marrow mesenchymal stem cell in patients with acute myocardial infarction. Am J Cardiol. 2004;94:92–95
  8. Lunde K, Solheim S, Aakhus S, Arnesen H, Abdelnoor M, Egeland T, et al. Intracoronary injection of mononuclear bone marrow cells in acute myocardial infarction. N Engl J Med. 2006;355:1199–1209
  9. Schächinger V, Erbs S, Elsässer A, Haberbosch W, Hambrecht R, Hölschermann H, et al. Intracoronary bone marrow–derived progenitor cells in acute myocardial infarction. N Engl J Med. 2006;355:1210–1221
  10. Assmus B, Honold J, Schächinger V, Britten MB, Fischer-Rasokat U, Lehmann R, et al. Transcoronary transplantation of progenitor cells after myocardial infarction. N Engl J Med. 2006;355:1222–1232
  11. Meyer GP, Wollert KC, Lotz J, Steffens J, Lippolt P, Fichtner S, et al. Intracoronary bone marrow cell transfer after myocardial infarction: eighteen months' follow-up data from the randomized, controlled BOOST (BOne marrOw transfer to enhance ST-elevation infarct regeneration) trial. Circulation. 2006;113:1287–1294
  12. Dimmeler S, Zeiher AM, Schneider MD. Unchain my heart: the scientific foundations of cardiac repair. J Clin Invest. 2005;115:572–583
  13. Fraser JK, Schreiber R, Strem B, Zhu M, Alfonso Z, Wulur I, et al. Plasticity of human adipose stem cells toward endothelial cells and cardiomyocytes. Nat Clin Pract Cardiovasc Med. 2006;3(Suppl 1):S33–S37
  14. De Coppi P, Bartsch G, Siddiqui MM, Xu T, Santos CC, Perin L, et al. Isolation of amniotic stem cell lines with potential for therapy. Nat Biotechnol. 2007;25:100–106
  15. Iop L, Chiavegato A, Callegari A, Bollini S, Piccoli M, Pozzobon M, et al. Different cardiovascular potential of adult- and fetal-type mesenchymal stem cells in a rat model of heart cryoinjury. Cell Transplant. In press 2008.
  16. Chiavegato A, Bollini S, Pozzobon M, Callegari A, Gasparotto L, Taiani J, et al. Human amniotic fluid–derived stem cells are rejected after transplantation in the myocardium of normal, ischemic, immuno-suppressed or immuno-deficient rat. J Mol Cell Cardiol. 2007;42:746–759
  17. Sartore S, Lenzi M, Angelini A, Chiavegato A, Gasparotto L, De Coppi P, et al. Amniotic mesenchymal cells autotransplanted in a porcine model of cardiac ischemia do not differentiate to cardiogenic phenotypes. Eur J Cardiothorac Surg. 2005;28:677–684
  18. Erbs S, Linke A, Schächinger V, Assmus B, Thiele H, Diederich KW, et al. Restoration of microvascular function in the infarct-related artery by intracoronary transplantation of bone marrow progenitor cells in patients with acute myocardial infarction: the Doppler Substudy of the Reinfusion of Enriched Progenitor Cells and Infarct Remodeling in Acute Myocardial Infarction (REPAIR-AMI) trial. Circulation. 2007;116:366–374
  19. Alperin C, Zandstra PW, Woodhouse KA. Polyurethane films seeded with embryonic stem cell–derived cardiomyocytes for use in cardiac tissue engineering applications. Biomaterials. 2005;26:7377–7386
  20. Neuss S, Apel C, Buttler P, Denecke B, Dhanasingh A, Ding X, et al. Assessment of stem cell/biomaterial combinations for stem cell–based tissue engineering. Biomaterials. 2008;29:302–313
  21. Wei J, Yoshinari M, Takemoto S, Hattori M, Kawada E, Liu B, et al. Adhesion of mouse fibroblasts on hexamethyldisiloxane surfaces with wide range of wet. J Biomed Mater Res B Appl Biomater. 2007;81:66–75
  22. Brétagnol F, Valsesia A, Ceccone G, Colpo P, Gilliland D, Cerotti L, et al. Surface functionalization and patterning techniques to design interfaces for biomedical and biosensor applications. Plasma Process Polym. 2006;3:443–455
  23. d'Agostino R, Favia P, Sardella E, Nardulli M, Lopez L, Pistillo BR, et al. Plasma tuning of surface chemistry for driving cell behavior. Proc of 18th International Symposium on Plasma Chemistry, International Plasma Chemistry Society, Publ, p. 658, August 26-31, 2007 Kyoto (Japan).
  24. Ozawa T, Mickle DA, Weisel RD, Koyama N, Ozawa S, Li RK. Optimal biomaterial for creation of autologous cardiac grafts. Circulation. 2002;106(12 Suppl. 1):I176–I182
  25. Zimmermann WH, Melnychenko I, Eschenhagen T. Engineered heart tissue for regeneration of diseased hearts. Biomaterials. 2004;25:1639–1647
  26. Menasché P, Hagège AA, Vilquin JT, Desnos M, Abergel E, Pouzet B, et al. Autologous skeletal myoblast transplantation for severe postinfarction left ventricular dysfunction. J Am Coll Cardiol. 2003;41:1078–1083
  27. Smits PC, van Geuns RJ, Poldermans D, Bountioukos M, Onderwater EE, Lee CH, et al. Catheter-based intramyocardial injection of autologous skeletal myoblasts as a primary treatment of ischemic heart failure: clinical experience with six-month follow-up. J Am Coll Cardiol. 2003;42:2063–2069
  28. Oettgen P, Boyle AJ, Schulman SP, Hare JM. Cardiac stem cell therapy. Need for optimization of efficacy and safety monitoring. Circulation. 2006;114:353–358
  29. Abraham MR, Henrikson CA, Tung L, Chang MG, Aon M, Xue T, et al. Antiarrhythmic engineering of skeletal myoblasts for cardiac transplantation. Circ Res. 2005;97:159–167
  30. Kang HJ, Kim HS, Zhang SY, Park KW, Cho HJ, Koo BK, et al. Effects of intracoronary infusion of peripheral blood stem-cells mobilised with granulocyte-colony stimulating factor on left ventricular systolic function and restenosis after coronary stenting in myocardial infarction: the MAGIC cell randomised clinical trial. Lancet. 2004;363:751–756
  31. Thomson JA, Itskovitz-Eldor J, Shapiro SS, Waknitz MA, Swiergiel JJ, Marshall VS, et al. Embryonic stem cell lines derived from human blastocysts. Science. 1998;282:1145–1147

PII: S0022-5223(07)02067-3

doi: 10.1016/j.jtcvs.2007.12.007

The Journal of Thoracic and Cardiovascular Surgery
Volume 135, Issue 5 , Pages 986-990 , May 2008

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