The Journal of Thoracic and Cardiovascular Surgery
Volume 135, Issue 4 , Pages 762-770.e1 , April 2008

Concomitant treatment with oral L-arginine improves the efficacy of surgical angiogenesis in patients with severe diffuse coronary artery disease: The Endothelial Modulation in Angiogenic Therapy randomized controlled trial

  • Marc Ruel, MD, MPH

      Affiliations

    • Division of Cardiac Surgery, University of Ottawa, Ottawa, Ontario, Canada
    • Department of Epidemiology, University of Ottawa, Ottawa, Ontario, Canada
    • Corresponding Author InformationAddress for reprints: Marc Ruel, MD, MPH, University of Ottawa Heart Institute, 40 Ruskin Street, Suite 3403, Ottawa, Ontario, Canada K1Y 4W7.
    • ,
  • Robert S. Beanlands, MD

      Affiliations

    • Division of Cardiology, University of Ottawa, Ottawa, Ontario, Canada
    • ,
  • Mireille Lortie, PhD

      Affiliations

    • Division of Cardiology, University of Ottawa, Ottawa, Ontario, Canada
    • ,
  • Vincent Chan, MD

      Affiliations

    • Division of Cardiac Surgery, University of Ottawa, Ottawa, Ontario, Canada
    • ,
  • Nancy Camack, RN

      Affiliations

    • Division of Cardiology, University of Toronto, Toronto, Ontario, Canada
    • ,
  • Robert A. deKemp, PhD

      Affiliations

    • Division of Cardiology, University of Ottawa, Ottawa, Ontario, Canada
    • ,
  • Erik J. Suuronen, PhD

      Affiliations

    • Division of Cardiac Surgery, University of Ottawa, Ottawa, Ontario, Canada
    • ,
  • Fraser D. Rubens, MD

      Affiliations

    • Division of Cardiac Surgery, University of Ottawa, Ottawa, Ontario, Canada
    • ,
  • Jean N. DaSilva, PhD

      Affiliations

    • Division of Cardiology, University of Ottawa, Ottawa, Ontario, Canada
    • ,
  • Frank W. Sellke, MD

      Affiliations

    • Department of Surgery, Harvard Medical School, Boston, Massachusetts
    • ,
  • Duncan J. Stewart, MD

      Affiliations

    • Division of Cardiology, University of Toronto, Toronto, Ontario, Canada
    • ,
  • Thierry G. Mesana, MD, PhD

      Affiliations

    • Division of Cardiac Surgery, University of Ottawa, Ottawa, Ontario, Canada

Received 4 May 2007 ,Revised 16 September 2007 ,Accepted 25 September 2007.

References 

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 Funded by grant NA5163 from the Heart and Stroke Foundation of Canada (M. Ruel). Duncan Stewart reports equity ownership of Northern Therapies, the manufacturer of the growth factor used in this study.

 Read at the Eighty-seventh Annual Meeting of The American Association for Thoracic Surgery, Washington, DC, May 5-9, 2007.

PII: S0022-5223(07)02026-0

doi: 10.1016/j.jtcvs.2007.09.073

The Journal of Thoracic and Cardiovascular Surgery
Volume 135, Issue 4 , Pages 762-770.e1 , April 2008

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