The Journal of Thoracic and Cardiovascular Surgery
Volume 136, Issue 1 , Pages 37-45.e1, July 2008

A self-renewing, tissue-engineered vascular graft for arterial reconstruction

  • Kei Torikai, MD

      Affiliations

    • Division of Cardiovascular Surgery, Department of Surgery, Osaka University Graduate School of Medicine, Osaka, Japan
    • ,
  • Hajime Ichikawa, MD, PhD

      Affiliations

    • Division of Cardiovascular Surgery, Department of Surgery, Osaka University Graduate School of Medicine, Osaka, Japan
    • ,
  • Koichiro Hirakawa, MS

      Affiliations

    • Senko Medical Instrument Manufacturing Co Ltd, Tokyo, Japan
    • ,
  • Goro Matsumiya, MD, PhD

      Affiliations

    • Division of Cardiovascular Surgery, Department of Surgery, Osaka University Graduate School of Medicine, Osaka, Japan
    • ,
  • Toru Kuratani, MD, PhD

      Affiliations

    • Division of Cardiovascular Surgery, Department of Surgery, Osaka University Graduate School of Medicine, Osaka, Japan
    • ,
  • Shigemitsu Iwai, MD, PhD

      Affiliations

    • Division of Cardiovascular Surgery, Department of Surgery, Osaka University Graduate School of Medicine, Osaka, Japan
    • ,
  • Atsuhiro Saito, PhD

      Affiliations

    • Division of Cardiovascular Surgery, Department of Surgery, Osaka University Graduate School of Medicine, Osaka, Japan
    • ,
  • Naomasa Kawaguchi, PhD

      Affiliations

    • Department of Pathology, Osaka University School of Allied Health Science, Osaka, Japan
    • ,
  • Nariaki Matsuura, MD, PhD

      Affiliations

    • Department of Pathology, Osaka University School of Allied Health Science, Osaka, Japan
    • ,
  • Yoshiki Sawa, MD, PhD

      Affiliations

    • Division of Cardiovascular Surgery, Department of Surgery, Osaka University Graduate School of Medicine, Osaka, Japan
    • Corresponding Author InformationAddress for reprints: Yoshiki Sawa, MD, PhD, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.

Received 29 December 2006; received in revised form 15 May 2007; accepted 25 June 2007.

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 We developed a tissue-engineered vascular graft for arterial reconstruction to facilitate renewing of autologous tissue without pretreatment and evaluated its utility in a porcine model. The graft showed morphologic evidence of good in situ cellularization, satisfactory durability against arterial pressure for 12 months, and potential to acquire vasomotor responsiveness.

 Supported by a grant from the Ministry of Economy, Trade, and Industry in the Japanese government.

PII: S0022-5223(07)01569-3

doi:10.1016/j.jtcvs.2007.06.039

The Journal of Thoracic and Cardiovascular Surgery
Volume 136, Issue 1 , Pages 37-45.e1, July 2008

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