The Journal of Thoracic and Cardiovascular Surgery
Volume 135, Issue 2 , Pages 240-242.e2 , February 2008

Improving neurologic and quality-of-life outcomes in children with congenital heart disease: Past, present, and future

  • Gil Wernovsky, MD

      Affiliations

    • Corresponding Author InformationAddress for reprints: Gil Wernovsky, MD, Pediatric Cardiology, 34th St and Civic Center Blvd, Philadelphia PA, 19104.

Received 6 April 2007 ,Revised 26 June 2007 ,Accepted 5 July 2007.

References 

  1. Wernovsky G. Current insights regarding neurological and developmental abnormalities in children and young adults with complex congenital cardiac disease. Cardiol Young. 2006;16(Suppl 1):92–104
  2. Newburger JW, Jonas RA, Soul J, Kussman BD, Bellinger DC, Laussen PC, et al. Randomized trial of hematocrit 25% versus 35% during hypothermic cardiopulmonary bypass in infant heart surgery. J Thorac Cardiovasc Surg. 2008;135:347–354
  3. Wypij D, Jonas RA, Bellinger DC, del Nido PJ, Mayer JE, Bacha EA, et al. The effect of hematocrit during hypothermic cardiopulmonary bypass in infant heart surgery: results from the combined Boston hematocrit trials. J Thorac Cardiovasc Surg. 2008;135:355–360
  4. Wypij D, Newburger JW, Rappaport LA, duPlessis AJ, Jonas RA, Wernovsky G, et al. The effect of duration of deep hypothermic circulatory arrest in infant heart surgery on late neurodevelopment: the Boston Circulatory Arrest Trial. J Thorac Cardiovasc Surg. 2003;126:1397–1403
  5. Bellinger DC, Wypij D, duPlessis AJ, Rappaport LA, Jonas RA, Wernovsky G, et al. Neurodevelopmental status at eight years in children with dextro-transposition of the great arteries: the Boston Circulatory Arrest Trial. J Thorac Cardiovasc Surg. 2003;126:1385–1396
  6. du Plessis AJ, Jonas RA, Wypij D, Hickey PR, Riviello J, Wessel DL, et al. Perioperative effects of alpha-stat versus pH-stat strategies for deep hypothermic cardiopulmonary bypass in infants. J Thorac Cardiovasc Surg. 1997;114:991–1000
  7. Gaynor JW, Gerdes M, Zackai EH, Bernbaum J, Wernovsky G, Clancy RR, et al. Apolipoprotein E genotype and neurodevelopmental sequelae of infant cardiac surgery. J Thorac Cardiovasc Surg. 2003;126:1736–1745
  8. Majnemer A, Limperopoulos C, Shevell M, Rohlicek C, Rosenblatt B, Tchervenkov C. Health and well-being of children with congenital cardiac malformations, and their families, following open-heart surgery. Cardiol Young. 2006;16:157–164
  9. Hovels-Gurich HH, Konrad K, Skorzenski D, Herpertz-Dahlmann B, Messmer BJ, Seghaye MC. Attentional dysfunction in children after corrective cardiac surgery in infancy. Ann Thorac Surg. 2007;83:1425–1430

PII: S0022-5223(07)01448-1

doi: 10.1016/j.jtcvs.2007.07.057

The Journal of Thoracic and Cardiovascular Surgery
Volume 135, Issue 2 , Pages 240-242.e2 , February 2008

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