The Journal of Thoracic and Cardiovascular Surgery
Volume 134, Issue 6 , Pages 1519-1525 , December 2007

Successful low-energy cardioversion using a novel biodegradable gel pad: Feasibility of treating postoperative atrial fibrillation in animals

  • Kenji Iino, MD

      Affiliations

    • Department of General and Cardiothoracic Surgery, Kanazawa University School of Medicine, Kanazawa, Japan
    • Corresponding Author InformationAddress for reprints: Kenji Iino, MD, Department of General and Cardiothoracic Surgery, Kanazawa University of Medicine, 13-1 Takaramachi, Kanazawa 920-8641, Japan.
    • ,
  • Nobuhiko Yui, PhD

      Affiliations

    • The School of Materials Science and the 21st Century COE Program, Japan Advanced Institute of Science and Technology, Nomi, Ishikawa, Japan.
    • ,
  • Tooru Ooya, PhD

      Affiliations

    • The School of Materials Science and the 21st Century COE Program, Japan Advanced Institute of Science and Technology, Nomi, Ishikawa, Japan.
    • ,
  • Ryouji Kawabata

      Affiliations

    • The School of Materials Science and the 21st Century COE Program, Japan Advanced Institute of Science and Technology, Nomi, Ishikawa, Japan.
    • ,
  • Shigeyuki Tomita, MD

      Affiliations

    • Department of General and Cardiothoracic Surgery, Kanazawa University School of Medicine, Kanazawa, Japan
    • ,
  • Go Watanabe, MD

      Affiliations

    • Department of General and Cardiothoracic Surgery, Kanazawa University School of Medicine, Kanazawa, Japan

Received 27 October 2006 ,Revised 25 February 2007 ,Accepted 26 April 2007.

  • Image Result

    Biodegradable gel pads.

    Biodegradable gel pads.

  • Image Result

    Location of 2 biodegradable gel pads for AF in anterior (A, B) and inferior (C) views of heart.

    Location of 2 biodegradable gel pads for AF in anterior (A, B) and inferior (C) views of heart.

  • Image Result

    Example of atrial defibrillation in pig model of pericarditis with biodegradable cardioversion gel pads. ECG, electrocardiogram; PV, pulmonary vein.

    Example of atrial defibrillation in pig model of pericarditis with biodegradable cardioversion gel pads. ECG, electrocardiogram; PV, pulmonary vein.

  • Image Result

    Gross (A, B) and histologic (C, D) assessments 1 month after surgery. Bar = 1000 μm. Epicardium and myocardium beneath (C) and without (D) gel pads. POD, Postoperative day.

    Gross (A, B) and histologic (C, D) assessments 1 month after surgery. Bar = 1000 μm. Epicardium and myocardium beneath (C) and without (D) gel pads. POD, Postoperative day.

 This study was supported by Chisso Co Ltd, Tokyo, Japan.

PII: S0022-5223(07)01306-2

doi: 10.1016/j.jtcvs.2007.04.073

The Journal of Thoracic and Cardiovascular Surgery
Volume 134, Issue 6 , Pages 1519-1525 , December 2007

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