The Journal of Thoracic and Cardiovascular Surgery
Volume 134, Issue 5 , Pages 1143-1149 , November 2007

Lipid-lowering effect of preoperative statin therapy on postoperative major adverse cardiac events after coronary artery bypass surgery

Read at the 79th Scientific Sessions of the American Heart Association, Chicago, Ill, November 12-15, 2006.

  • Matthias Thielmann, MD

      Affiliations

    • Department of Thoracic and Cardiovascular Surgery, West German Heart Center Essen, University Hospital Essen, Essen, Germany
    • Corresponding Author InformationAddress for reprints: Matthias Thielmann, MD, Department of Thoracic and Cardiovascular Surgery, West German Heart Center Essen, University Hospital Essen, Hufelandstraße 55, 45122 Essen, Germany.
    • ,
  • Markus Neuhäuser, PhD

      Affiliations

    • Institute for Medical Informatics, Biometry, and Epidemiology, University Hospital Essen, Essen, Germany.
    • ,
  • Anja Marr

      Affiliations

    • Institute for Medical Informatics, Biometry, and Epidemiology, University Hospital Essen, Essen, Germany.
    • ,
  • Beate R. Jaeger, MD

      Affiliations

    • Department of Cardiology, West German Heart Center Essen, University Hospital Essen, Essen, Germany
    • ,
  • Daniel Wendt, MD

      Affiliations

    • Department of Thoracic and Cardiovascular Surgery, West German Heart Center Essen, University Hospital Essen, Essen, Germany
    • ,
  • Bernd Schuetze, PhD

      Affiliations

    • Department of Thoracic and Cardiovascular Surgery, West German Heart Center Essen, University Hospital Essen, Essen, Germany
    • ,
  • Markus Kamler, MD, PhD

      Affiliations

    • Department of Thoracic and Cardiovascular Surgery, West German Heart Center Essen, University Hospital Essen, Essen, Germany
    • ,
  • Parwis Massoudy, MD, PhD

      Affiliations

    • Department of Thoracic and Cardiovascular Surgery, West German Heart Center Essen, University Hospital Essen, Essen, Germany
    • ,
  • Raimund Erbel, MD, PhD

      Affiliations

    • Department of Cardiology, West German Heart Center Essen, University Hospital Essen, Essen, Germany
    • ,
  • Heinz Jakob, MD, PhD

      Affiliations

    • Department of Thoracic and Cardiovascular Surgery, West German Heart Center Essen, University Hospital Essen, Essen, Germany

Received 17 April 2007 ,Revised 14 July 2007 ,Accepted 26 July 2007.

References 

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  2. Shepherd J, Cobbe SM, Ford I, et al. Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia. N Engl J Med. 1995;333:1301–1308
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  4. O’Neil-Callahan K, Katsimaglis G, Tepper MR, et al. Statins decrease perioperative cardiac complications in patients undergoing noncardiac vascular surgery: the Statins for Risk Reduction in Surgery (StaRRS) study. J Am Coll Cardiol. 2005;45:336–342
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  7. Clark LL, Ikonomidis JS, Crawford J, et al. Preoperative statin treatment is associated with reduced postoperative mortality and morbidity in patients undergoing cardiac surgery: an 8-year retrospective cohort study. J Thorac Cardiovasc Surg. 2006;131:679–685
  8. Collard CD, Body SC, Shernan SK, et al. Preoperative statin therapy is associated with reduced cardiac mortality after coronary artery bypass graft surgery. J Thorac Cardiovasc Surg. 2006;132:392–400
  9. Powell BD, Bybee KA, Valeti U, et al. Influence of preoperative lipid-lowering therapy on postoperative outcome in patients undergoing coronary artery bypass grafting. Am J Cardiol. 2007;99:785–789
  10. Thielmann M, Leyh R, Massoudy P, et al. Prognostic significance of multiple previous percutaneous coronary interventions in patients undergoing elective coronary artery bypass surgery. Circulation. 2006;114(suppl):I441–I447
  11. Thielmann M, Massoudy P, Schmermund A, et al. Diagnostic discrimination between graft-related and non-graft-related perioperative myocardial infarction with cardiac troponin I after coronary artery bypass surgery. Eur Heart J. 2005;26:2440–2447
  12. Brookmeyer R, Liang K, Linet M. Matched case-control designs and overmatched analyses. Am J Epidemiol. 1986;124:693–701
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  14. Stein EA, Illingworth DR, Kwiterovich PO, et al. Efficacy and safety of lovastatin in adolescent males with heterozygous familial hypercholesterolemia: a randomized controlled trial. JAMA. 1999;281:137–144
  15. The Post Coronary Artery Bypass Graft Trial Investigators. The effect of aggressive lowering of low-density lipoprotein cholesterol levels and low-dose anticoagulation on obstructive changes in saphenous-vein coronary-artery bypass grafts. N Engl J Med. 1997;336:153–163
  16. Campeau L, Hunninghake DB, Knatterud GL, et al. Aggressive cholesterol lowering delays saphenous vein graft atherosclerosis in women, the elderly, and patients with associated risk factors: NHLBI Post Coronary Artery Bypass Graft Clinical Trial. Circulation. 1999;99:3241–3247
  17. Lenderink T, Boersma E, Gitt AK, et al. Patients using statin treatment within 24 h after admission for ST-elevation acute coronary syndromes had lower mortality than non-users: a report from the first Euro Heart Survey on acute coronary syndromes. Eur Heart J. 2006;27:1799–1804
  18. Herrmann J, Lerman A, Baumgart D, et al. Preprocedural statin medication reduces the extent of periprocedural non-Q-wave myocardial infarction. Circulation. 2002;106:2180–2183
  19. Grundy SM, Cleeman JI, Merz CNB, et al. Implications of recent clinical trials for the national cholesterol education program adult treatment panel III guidelines. Circulation. 2004;110:227–239
  20. Erbel R, Heusch G. Brief review: coronary microembolization. J Am Coll Cardiol. 2000;36:22–24
  21. Herrmann J. Peri-procedural myocardial injury: 2005 update. Eur Heart J. 2005;26:2493–2519
  22. Briguori C, Colombo A, Airoldi F, et al. Statin administration before percutaneous coronary intervention: impact on periprocedural myocardial infarction. Eur Heart J. 2004;25:1822–1828
  23. Chello M, Anselmi A, Spadaccio C, et al. Simvastatin increases neutrophil apoptosis and reduces inflammatory reaction after coronary surgery. Ann Thorac Surg. 2007;83:1374–1380
  24. Liakopoulos OJ, Dorge H, Schmitto JD, et al. Effects of preoperative statin therapy on cytokines after cardiac surgery. Thorac Cardiovasc Surg. 2006;54:250–254
  25. Pascual DA, Arribas JM, Tornel PL, et al. Preoperative statin therapy and troponin T predict early complications of coronary artery surgery. Ann Thorac Surg. 2006;81:78–83

 Supported by a research grant of the “Kulturstiftung Essen e.V.,” Essen, Germany.

PII: S0022-5223(07)01290-1

doi: 10.1016/j.jtcvs.2007.07.029

The Journal of Thoracic and Cardiovascular Surgery
Volume 134, Issue 5 , Pages 1143-1149 , November 2007

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