The Journal of Thoracic and Cardiovascular Surgery
Volume 134, Issue 3 , Pages 574-578 , September 2007

Left ventricular pacing site and timing optimization during biventricular pacing using a multielectrode patch in pigs

  • George Berberian, MD

      Affiliations

    • Departments of Surgery,
    • ,
  • T. Alexander Quinn, MS

      Affiliations

    • Biomedical Engineering,
    • ,
  • Santos E. Cabreriza, MBA

      Affiliations

    • Departments of Surgery,
    • ,
  • Jon-Emile S. Kenny, BS

      Affiliations

    • Departments of Surgery,
    • ,
  • Cara A. Garofalo, MD

      Affiliations

    • Pediatrics,
    • ,
  • Alan D. Weinberg, MS

      Affiliations

    • Biostatistics, Columbia University, College of Physicians and Surgeons, New York, NY
    • ,
  • Henry M. Spotnitz, MD

      Affiliations

    • Departments of Surgery,
    • George H. Humphreys, II Professor of Surgery.
    • Corresponding Author InformationAddress for reprints: Henry M. Spotnitz, MD, Department of Surgery, Columbia College of Physicians and Surgeons, 622 West 168th St, PH 14-103, New York, NY 10032

Received 21 September 2006 ,Revised 11 March 2007 ,Accepted 25 April 2007.

References 

  1. Gras D, Leclercq C, Tang AS, Bucknall C, Luttikhuis HO, Kirstein-Pedersen A. Cardiac resynchronization therapy in advanced heart failure the multicenter InSync clinical study. Eur J Heart Fail. 2002;4:311–320
  2. Cazeau S, LeClerq C, Lavergne T, Walker S, Varma C, Linde C, et al. Effects of multi-site biventricular pacing in patients with heart failure and intraventricular conduction delay. N Engl J Med. 2001;344:873–880
  3. Abraham WT, Fisher WG, Smith AL, Delurgio DB, Leon AR, Loh E, et al. Cardiac resynchronization in chronic heart failure. N Engl J Med. 2002;346:1845–1853
  4. Dean DA, Chao-Xiang J, Cabreriza S, D'Alessandro DA, Spotnitz HM. Validation study of a new transit time ultrasonic flow probe for continuous great vessel measurements. ASAIO J. 1996;42:M671–M676
  5. Prinzen FW, van Oosterhout MFM, Vanagt WYR, Storm C, Reneman RS. Optimization of ventricular function by improving the activation sequence during ventricular pacing. Pacing Clin Electrophysiol. 1998;21(11 Pt 2):2256–2260
  6. Yu Y, Kramer A, Spinelli J, Ding J, Hoersch W, Auricchio A. Biventricular mechanical asynchrony predicts hemodynamic effect of uni- and biventricular pacing. Am J Physiol Heart Circ Physiol. 2003;285:H2788–H2796
  7. Auricchio A, Klein H, Tockman B, Sack S, Stellbrink C, Neuzner J, et al. Transvenous biventricular pacing for heart failure: can the obstacles be oversome?. Am J Cardiol. 1999;83(5B):136D–142D
  8. Butter C, Auricchio A, Stellbrink C, Schlegl M, Fleck E, Horsch W, et al. Should stimulation site be tailored in the individual heart failure patient?. Am J Cardiol. 2000;86(9 Suppl 1):144K–151K
  9. Pappone C, Rosanio S, Oreto G, Tocchi M, Gulletta S, Salvati A, et al. Cardiac pacing in heart failure patients with left bundle branch block: impact of pacing site for optimizing left ventricular resynchronization. Ital Heart J. 2000;1:464–469
  10. Ansalone G, Giannantoni P, Ricci R, Trambaiolo P, Fedele F, Santini M. Doppler myocardial imaging to evaluate the effectiveness of pacing sites in patients receiving biventricular pacing. J Am Coll Cardiol. 2002;39:489–499
  11. Alonso C, Leclercq C, d'Allonnes FR, Pavin D, Victor F, Mabo P, et al. Six year experience of transvenous left ventricular lead implantation for permanent biventricular pacing in patients with advanced heart failure: technical aspects. Heart. 2001;86:405–410
  12. Valls-Bertault V, Mansourati J, Gilard M, Etienne Y, Munier S, Blanc JJ. Adverse events with transvenous left ventricular pacing in patients with severe heart failure: early experience from a single centre. Europace. 2001;3:60–63
  13. Dekker LAJ, Phelps B, Dijkman B, van der Nagel T, van der Veen FH, Geskes GG, et al. Epicardial left ventricular lead placement for cardiac resynchronization therapy: optimal pace site selection with pressure-volume loops. J Thorac Cardiovasc Surg. 2004;127:1641–1647
  14. Leon AR, Abraham WT, Brozena S, Daubert JP, Fisher WG, Gurley JC, et al. Cardiac resynchronization with sequential biventricular pacing for the treatment of moderate-to-severe heart failure. J Am Coll Cardiol. 2005;46:2298–2304
  15. Rabkin DG, Cabreriza SE, Curtis LJ, Mazer SP, Kanter JP, Weinberg AD, et al. Load dependence of cardiac output in biventricular pacing: right ventricular pressure overload in pigs. J Thorac Cardiovasc Surg. 2004;127:1713–1722
  16. Rabkin DG, Cabreriza SE, Curtis LJ, Quinn TA, Weinberg AD, Hordof AD, et al. Mechanisms of optimized biventricular pacing in pulmonary stenosis: effects on left ventricular geometry in swine. Pacing Clin Electrophysiol. 2004;27:1060–1071
  17. Quinn TA, Berberian G, Cabreriza SE, Maskin LJ, Weinberg AD, Holmes JW, et al. Effects of sequential biventricular pacing during acute right ventricular pressure overload. Am J Physiol Heart Circ Physiol. 2006;291:H2380–H2387
  18. Berberian G, Cabreriza SE, Quinn TA, Garofalo CA, Spotnitz HM. Left ventricular pacing site-timing optimization during biventricular pacing using a multi-electrode patch. Ann Thorac Surg. 2006;82:2292–2294
  19. Berberian G, Quinn TA, Cabreriza SE, Garofalo CA, Barrios DM, Weinberg AD, et al. Load dependence of cardiac output in biventricular pacing: left ventricular volume overload in pigs. J Thorac Cardiovasc Surg. 2006;131:666–670

 Supported in part by the National Heart, Lung and Blood Institute of the National Institutes of Health (RO1 HL 48109 to Dr Spotnitz) and in part by the Department of Surgery, Columbia University College of Physicians and Surgeons.

PII: S0022-5223(07)00872-0

doi: 10.1016/j.jtcvs.2007.04.050

The Journal of Thoracic and Cardiovascular Surgery
Volume 134, Issue 3 , Pages 574-578 , September 2007

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