The Journal of Thoracic and Cardiovascular Surgery
Volume 134, Issue 3 , Pages 565-573 , September 2007

Bone marrow–derived mononuclear cell transplantation improves myocardial recovery by enhancing cellular recruitment and differentiation at the infarction site

  • Jussi Mäkelä, BM

      Affiliations

    • Department of Surgery, Clinical Research Center, Oulu University Hospital, University of Oulu, Oulu, Finland
    • ,
  • Kari Ylitalo, MD, PhD

      Affiliations

    • Department of Cardiology, Clinical Research Center, Oulu University Hospital, University of Oulu, Oulu, Finland
    • ,
  • Siri Lehtonen, PhD

      Affiliations

    • Department of Surgery, Clinical Research Center, Oulu University Hospital, University of Oulu, Oulu, Finland
    • ,
  • Sebastian Dahlbacka, MD

      Affiliations

    • Department of Surgery, Clinical Research Center, Oulu University Hospital, University of Oulu, Oulu, Finland
    • ,
  • Eija Niemelä, BM

      Affiliations

    • Department of Surgery, Clinical Research Center, Oulu University Hospital, University of Oulu, Oulu, Finland
    • ,
  • Kai Kiviluoma, MD, PhD

      Affiliations

    • Department of Anaesthesiology, Clinical Research Center, Oulu University Hospital, University of Oulu, Oulu, Finland.
    • ,
  • Jussi Rimpiläinen, MD, PhD

      Affiliations

    • Department of Surgery, Clinical Research Center, Oulu University Hospital, University of Oulu, Oulu, Finland
    • ,
  • Hanna Alaoja, BM

      Affiliations

    • Department of Surgery, Clinical Research Center, Oulu University Hospital, University of Oulu, Oulu, Finland
    • ,
  • Timo Paavonen, MD, PhD

      Affiliations

    • Department of Pathology, Clinical Research Center, Oulu University Hospital, University of Oulu, Oulu, Finland
    • ,
  • Petri Lehenkari, MD, PhD

      Affiliations

    • Department of Surgery, Clinical Research Center, Oulu University Hospital, University of Oulu, Oulu, Finland
    • Drs Lehenkari, Juvonen, and Anttila all contributed equally to this study.
    • ,
  • Tatu Juvonen, MD, PhD

      Affiliations

    • Department of Surgery, Clinical Research Center, Oulu University Hospital, University of Oulu, Oulu, Finland
    • Drs Lehenkari, Juvonen, and Anttila all contributed equally to this study.
    • Corresponding Author InformationAddress for reprints: Professor Tatu Juvonen, Department of Surgery, Oulu University Hospital, PO Box 21, 90029 Oulu, Finland.
    • ,
  • Vesa Anttila, MD, PhD

      Affiliations

    • Department of Surgery, Clinical Research Center, Oulu University Hospital, University of Oulu, Oulu, Finland
    • Drs Lehenkari, Juvonen, and Anttila all contributed equally to this study.

Received 25 February 2007 ,Revised 18 April 2007 ,Accepted 2 May 2007.

References 

  1. Shake JG, Gruber PJ, Baumgartner WA, Senechal G, Meyers J, Redmond JM, et al. Mesenchymal stem cell implantation in a swine myocardial infarct model: engraftment and functional effects. Ann Thorac Surg. 2002;73:1919–1925
  2. Amado LC, Saliaris AP, Schuleri KH, St John M, Xie JS, Cattaneo S, et al. Cardiac repair with intramyocardial injection of allogeneic mesenchymal stem cells after myocardial infarction. Proc Natl Acad Sci U S A. 2005;102:11474–11479
  3. MacDonald DJ, Luo J, Saito T, Duong M, Bernier PL, Chiu RC, et al. Persistence of marrow stromal cells implanted into acutely infarcted myocardium: observations in a xenotransplant model. J Thorac Cardiovasc Surg. 2005;130:1114–1121
  4. Makino S, Fukuda K, Miyoshi S, Konishi F, Kodama H, Pan J, et al. Cardiomyocytes can be generated from marrow stromal cells in vitro. J Clin Invest. 1999;103:697–705
  5. Orlic D, Kajstura J, Chimenti S, Limana F, Jakoniuk I, Quaini F, et al. Mobilized bone marrow cells repair the infarcted heart, improving function and survival. Proc Natl Acad Sci U S A. 2001;98:10344–10349
  6. Orlic D, Kajstura J, Chimenti S, Jakoniuk I, Anderson SM, Li B, et al. Bone marrow cells regenerate infarcted myocardium. Nature. 2001;410:701–705
  7. Pittenger MF, Mackay AM, Beck SC, Jaiswal RK, Douglas R, Mosca JD, et al. Multilineage potential of adult human mesenchymal stem cells. Science. 1999;284:143–147
  8. Tang YL, Zhao Q, Zhang YC, Cheng L, Liu M, Shi J, et al. Autologous mesenchymal stem cell transplantation induce VEGF and neovascularization in ischemic myocardium. Regul Pept. 2004;117:3–10
  9. Heil M, Ziegelhoeffer T, Mees B, Schaper W. A different outlook on the role of bone marrow stem cells in vascular growth: bone marrow delivers software not hardware. Circ Res. 2004;94:573–574
  10. Kucia M, Dawn B, Hunt G, Guo Y, Wysoczynski M, Majka M, et al. Cells expressing early cardiac markers reside in the bone marrow and are mobilized into the peripheral blood after myocardial infarction. Circ Res. 2004;95:1191–1199
  11. Assmus B, Schachinger V, Teupe C, Britten M, Lehmann R, Dobert N, et al. Transplantation of Progenitor Cells and Regeneration Enhancement in Acute Myocardial Infarction (TOPCARE-AMI). Circulation. 2002;106:3009–3017
  12. Schachinger V, Tonn T, Dimmeler S, Zeiher AM. Bone-marrow-derived progenitor cell therapy in need of proof of concept: design of the REPAIR-AMI trial. Nat Clin Pract Cardiovasc Med. 2006;3(suppl 1):S23–S28
  13. Wollert KC, Meyer GP, Lotz J, Ringes-Lichtenberg S, Lippolt P, Breidenbach C, et al. Intracoronary autologous bone-marrow cell transfer after myocardial infarction: the BOOST randomised controlled clinical trial. Lancet. 2004;364:141–148
  14. Lunde K, Solheim S, Aakhus S, Arnesen H, Abdelnoor M, Forfang K. Autologous stem cell transplantation in acute myocardial infarction: The ASTAMI randomized controlled trial (Intracoronary transplantation of autologous mononuclear bone marrow cells, study design and safety aspects). Scand Cardiovasc J. 2005;39:150–158
  15. Strauer BE, Brehm M, Zeus T, Kostering M, Hernandez A, Sorg RV, et al. Repair of infarcted myocardium by autologous intracoronary mononuclear bone marrow cell transplantation in humans. Circulation. 2002;106:1913–1918
  16. Stamm C, Westphal B, Kleine HD, Petzsch M, Kittner C, Klinge H, et al. Autologous bone-marrow stem-cell transplantation for myocardial regeneration. Lancet. 2003;361:45–46
  17. Devereux RB, Alonso DR, Lutas EM, Gottlieb GJ, Campo E, Sachs I, et al. Echocardiographic assessment of left ventricular hypertrophy: comparison to necropsy findings. Am J Cardiol. 1986;57:450–458
  18. Teichholz LE, Kreulen T, Herman MV, Gorlin R. Problems in echocardiographic volume determinations: echocardiographic-angiographic correlations in the presence or absence of asyrgy. Am J Cardiol. 1976;37:7–11
  19. Sun Y, Weber KT. Infarct scar: a dynamic tissue. Cardiovasc Res. 2000;46:250–256
  20. Vracko R, Thorning D. Contractile cells in rat myocardial scar tissue. Lab Invest. 1991;65:214–227
  21. Virag JI, Murry CE. Myofibroblast and endothelial cell proliferation during murine myocardial infarct repair. Am J Pathol. 2003;163:2433–2440

 The study was supported by the Finnish Heart Research Foundation.

PII: S0022-5223(07)00770-2

doi: 10.1016/j.jtcvs.2007.05.004

The Journal of Thoracic and Cardiovascular Surgery
Volume 134, Issue 3 , Pages 565-573 , September 2007

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