The Journal of Thoracic and Cardiovascular Surgery
Volume 134, Issue 2 , Pages 504-505 , August 2007

A randomized trial of an external Dacron sheath for the prevention of vein graft disease: The Extent study

  • Gavin J. Murphy, MD, FRCS

      Affiliations

    • Corresponding Author InformationAddress for reprints: Mr GJ Murphy, Bristol Heart Institute, Bristol Royal Infirmary, Marlborough Street, Bristol BS6 5SJ, United Kingdom. Telephone: 0044 117928 3145, Fax: 0044 1179299737.
    • ,
  • Andrew C. Newby, BA, PhD

      Affiliations

    • Andrew Newby and Gianni Angelini are employees of the University of Bristol, which holds a patent on the concept of the external vascular stent.
    • ,
  • Jamie Y. Jeremy, PhD
    • ,
  • Andreas Baumbach, MD, FRCP
    • ,
  • Gianni D. Angelini, MD, FRCS

      Affiliations

    • Andrew Newby and Gianni Angelini are employees of the University of Bristol, which holds a patent on the concept of the external vascular stent.

References 

  1. The Society of Cardiothoracic Surgeons of Great Britain and Ireland National Adult Cardiac Surgical Database Report 2003. Dendrite Clinical Systems; Oxforshire [UK].
  2. Goldman S, Zadina K, Moritz T, Ovitt Sethi TG, Copeland JG, et al. VA Cooperative Study Group #207/297/364 Long-term patency of saphenous vein and left internal mammary artery grafts after coronary artery bypass surgery results from a Department of Veterans Affairs Cooperative Study. J Am Coll Cardiol. 2004;44:2149–2156
  3. Mehta D, George SJ, Jeremy JY, Izzat MB, Southgate KM, Bryan AJ, et al. External stenting reduces long-term medial and neointimal thickening and platelet derived growth factor expression in a pig model of arteriovenous bypass grafting. Nat Med. 1998;4:235–239
  4. Angelini GD, Lloyd C, Bush R, Johnson J, Newby AC. An external, oversized, porous polyester stent reduces vein graft neointima formation, cholesterol concentration, and vascular cell adhesion molecule 1 expression in cholesterol-fed pigs. J Thorac Cardiovasc Surg. 2002;124:950–956
  5. Vijayan V, Shukla N, Johnson JL, Gadsdon P, Angelini GD, Smith FC, et al. Long-term reduction of medial and intimal thickening in porcine saphenous vein grafts with a polyglactin biodegradable external sheath. J Vasc Surg. 2004;40:1011–1019

 Funded by the British Heart Foundation.

PII: S0022-5223(07)00674-5

doi: 10.1016/j.jtcvs.2007.01.092

The Journal of Thoracic and Cardiovascular Surgery
Volume 134, Issue 2 , Pages 504-505 , August 2007

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