Randomized trial of hematocrit 25% versus 35% during hypothermic cardiopulmonary bypass in infant heart surgery

Newburger, Jane W.; Jonas, Richard A.; Soul, Janet; Kussman, Barry D.; Bellinger, David C.; Laussen, Peter C.; Robertson, Richard; Mayer, John E.; del Nido, Pedro J.; Bacha, Emile A.; Forbess, Joseph M.; Pigula, Frank; Roth, Stephen J.; Visconti, Karen J.; du Plessis, Adre J.; Farrell, David M.; McGrath, Ellen; Rappaport, Leonard A.; Wypij, David

doi:10.1016/j.jtcvs.2007.01.051

« Previous Next »The Journal of Thoracic and Cardiovascular Surgery
Volume 135, Issue 2 , Pages 347-354.e4, February 2008

Randomized trial of hematocrit 25% versus 35% during hypothermic cardiopulmonary bypass in infant heart surgery

Jane W. Newburger, MD, MPH
- Department of Cardiology, Children’s Hospital Boston, Boston, Mass
- Department of Pediatrics, Harvard Medical School, Boston, Mass
- Address for reprints: Jane W. Newburger, MD, MPH, Department of Cardiology, Children’s Hospital Boston, 300 Longwood Ave, Boston, MA 02115.
Richard A. Jonas, MD
- Department of Cardiovascular Surgery, Children’s Hospital Boston, Boston, Mass
- Department of Surgery, Harvard Medical School, Boston, Mass
- Dr Jonas is currently Chief of Cardiovascular Surgery and Co-director of the Children’s National Heart Institute, Washington, DC.
Janet Soul, MD
- Department of Neurology, Children’s Hospital Boston, Boston, Mass
- Department of Neurology, Harvard Medical School, Boston, Mass
Barry D. Kussman, MBBCh
- Department of Anesthesiology, Children’s Hospital Boston, Boston, Mass
- Department of Anesthesia, Harvard Medical School, Boston, Mass
David C. Bellinger, PhD, MSc
- Department of Neurology, Children’s Hospital Boston, Boston, Mass
- Department of Neurology, Harvard Medical School, Boston, Mass
Peter C. Laussen, MD
- Department of Cardiology, Children’s Hospital Boston, Boston, Mass
- Department of Anesthesia, Harvard Medical School, Boston, Mass
Richard Robertson, MD
- Department of Radiology, Children’s Hospital Boston, Boston, Mass
- Department of Radiology Harvard Medical School, Boston, Mass
John E. Mayer Jr, MD
- Department of Cardiovascular Surgery, Children’s Hospital Boston, Boston, Mass
- Department of Surgery, Harvard Medical School, Boston, Mass
Pedro J. del Nido, MD
- Department of Cardiovascular Surgery, Children’s Hospital Boston, Boston, Mass
- Department of Surgery, Harvard Medical School, Boston, Mass
Emile A. Bacha, MD
- Department of Cardiovascular Surgery, Children’s Hospital Boston, Boston, Mass
- Department of Surgery, Harvard Medical School, Boston, Mass
Joseph M. Forbess, MD
- Department of Cardiovascular Surgery, Children’s Hospital Boston, Boston, Mass
- Department of Surgery, Harvard Medical School, Boston, Mass
- Dr Forbess is currently at Children’s Medical Center Dallas.
Frank Pigula, MD
- Department of Cardiovascular Surgery, Children’s Hospital Boston, Boston, Mass
Stephen J. Roth, MD, MPH
- Department of Cardiology, Children’s Hospital Boston, Boston, Mass
Karen J. Visconti, PhD
- Department of Cardiovascular Surgery, Children’s Hospital Boston, Boston, Mass
Adre J. du Plessis, MBChB, MPH
- Department of Neurology, Children’s Hospital Boston, Boston, Mass
- Department of Neurology, Harvard Medical School, Boston, Mass
David M. Farrell, MA, CCP
- Department of Cardiovascular Surgery, Children’s Hospital Boston, Boston, Mass
Ellen McGrath, RN
- Department of Cardiology, Children’s Hospital Boston, Boston, Mass
Leonard A. Rappaport, MD
- Department of Pediatrics, Children’s Hospital Boston, Boston, Mass
- Department of Pediatrics, Harvard Medical School, Boston, Mass
David Wypij, PhD
- Department of Cardiology, Children’s Hospital Boston, Boston, Mass
- Department of Pediatrics, Harvard Medical School, Boston, Mass
- Department of Biostatistics, Harvard School of Public Health, Boston, Mass.

Received 11 October 2006; received in revised form 9 January 2007; accepted 29 January 2007.

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Registered with clinicaltrials.gov (#) NCT00006183

Supported by grants HL 063411 and RR 02172 from the National Institutes of Health and by the Farb Family Fund.

PII: S0022-5223(07)00299-1

doi:10.1016/j.jtcvs.2007.01.051

Refers to article:

Improving neurologic and quality-of-life outcomes in children with congenital heart disease: Past, present, and future
Gil Wernovsky
The Journal of Thoracic and Cardiovascular Surgery February 2008 (Vol. 135, Issue 2, Pages 240-242.e2)
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The effect of hematocrit during hypothermic cardiopulmonary bypass in infant heart surgery: Results from the combined Boston hematocrit trials
David Wypij, Richard A. Jonas, David C. Bellinger, Pedro J. Del Nido, John E. Mayer, Emile A. Bacha, Joseph M. Forbess, Frank Pigula, Peter C. Laussen, Jane W. Newburger
The Journal of Thoracic and Cardiovascular Surgery February 2008 (Vol. 135, Issue 2, Pages 355-360)