The Journal of Thoracic and Cardiovascular Surgery
Volume 133, Issue 6 , Pages 1588-1596 , June 2007

Lipopolysaccharide preconditioning induces robust protection against brain injury resulting from deep hypothermic circulatory arrest

Presented as a poster presentation at the Thirty-second Annual Meeting of the Western Thoracic Surgical Association, Sun Valley, Idaho, June 21-24, 2006.

  • Edward J. Hickey, MRCS

      Affiliations

    • Department of Pediatric Cardiac Surgery, Oregon Health Sciences University, Portland, Ore
    • Corresponding Author InformationAddress for reprints: Edward J. Hickey, MD, CHSS Data Center, Hospital for Sick Children, 555 University Ave, Toronto, Ontario M5G 1X8, Canada.
    • ,
  • Xiaomang You, MD

      Affiliations

    • Department of Pediatric Cardiac Surgery, Oregon Health Sciences University, Portland, Ore
    • ,
  • Vassil Kaimaktchiev, MD

      Affiliations

    • Department of Neuropathology, Oregon Health Sciences University, Portland, Ore
    • ,
  • Mary Stenzel-Poore, PhD

      Affiliations

    • Department of Immunology, Oregon Health Sciences University, Portland, Ore.
    • ,
  • Ross M. Ungerleider, MD

      Affiliations

    • Department of Pediatric Cardiac Surgery, Oregon Health Sciences University, Portland, Ore

Received 27 July 2006 ,Revised 15 November 2006 ,Accepted 18 December 2006.

  • Image Result

    Graphic illustration of the histologic injury in frontal lobe cortex, basal ganglia, and hippocampus occurring in the LPS-preconditioned and saline control groups, as determined by routine light micro

    Graphic illustration of the histologic injury in frontal lobe cortex, basal ganglia, and hippocampus occurring in the LPS-preconditioned and saline control groups, as determined by routine light microscopy. **P < .01; n/s, not significant. Cor, Cortex; BG, basal ganglia; HC, hippocampus; LPS, lipopolysaccharide.

  • Image Result
    Graphic illustration of the histologic injury in frontal lobe cortex, basal ganglia, and hippocampus occurring in the LPS-preconditioned and saline control groups, as determined by FluoroJade staining

    Graphic illustration of the histologic injury in frontal lobe cortex, basal ganglia, and hippocampus occurring in the LPS-preconditioned and saline control groups, as determined by FluoroJade staining. **P <. 01. Cor, Cortex; BG, basal ganglia; HC, hippocampus; LPS, lipopolysaccharide.

  • Image Result
    Representative images of hippocampal (dentate gyrus) sections from LPS-preconditioned and saline control (unpreconditioned) brains stained with Fluoro-Jade as viewed through a fluorescent microcope. T

    Representative images of hippocampal (dentate gyrus) sections from LPS-preconditioned and saline control (unpreconditioned) brains stained with Fluoro-Jade as viewed through a fluorescent microcope. The positive cells are clearly discernible, littering the granular cell layer of the dentate. LPS, Lipopolysaccharide.

 Supported by generous grants from the Medical Research Foundation of Oregon and the Children’s Heart Foundation, which have funded both this study and the considerable preliminary work necessary.

PII: S0022-5223(07)00243-7

doi: 10.1016/j.jtcvs.2006.12.056

The Journal of Thoracic and Cardiovascular Surgery
Volume 133, Issue 6 , Pages 1588-1596 , June 2007

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