The Journal of Thoracic and Cardiovascular Surgery
Volume 133, Issue 6 , Pages 1419-1427.e4 , June 2007

Fluorine-18 fluorodeoxyglucose positron emission tomographic maximal standardized uptake value predicts survival independent of clinical but not pathologic TNM staging of resected non–small cell lung cancer

Read at the Eighty-sixth Annual Meeting of The American Association for Thoracic Surgery, Philadelphia, Pa, April 29-May 3, 2006.

  • Robert J. Downey, MD

      Affiliations

    • Thoracic Surgery Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY
    • Corresponding Author InformationAddress for reprints: Robert J. Downey, MD, Thoracic Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, 1275 York Ave, New York, NY 10021.
  • ,
  • Timothy Akhurst, MBBS, FRACP

      Affiliations

    • Division of Nuclear Medicine, Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, NY
  • ,
  • Mithat Gonen, PhD

      Affiliations

    • Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, NY.
  • ,
  • Bernard Park

      Affiliations

    • Thoracic Surgery Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY
  • ,
  • Valerie Rusch, MD

      Affiliations

    • Thoracic Surgery Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY

Received 29 June 2006 ,Revised 6 December 2006 ,Accepted 8 January 2007.

References 

  1. Duhaylongsod FG, Lowe VJ, Patz EF, Vaugh Al, Coleman RE, Wolfe WG. Lung tumor growth correlates with glucose metabolism measured by fluorine-18 fluorodeoxyglucose positron emission tomography. Ann Thorac Surg. 1995;60:1348–1352
  2. Vesselle H, Schmidt RA, Pugsley JM, Li M, Kohlmyer SG, Vallires E, et al. Lung cancer proliferation correlates with [F-18] fluorodeoxyglucose uptake by positron emission tomography. Clin Cancer Res. 2000;6:3837–3844
  3. Downey RJ, Akhurst T, Gonen M, Vincent A, Bains MS, Larson S, et al. Preoperative F-18 fluorodeoxyglucose-positron emission tomography maximal standardized uptake value predicts survival after lung cancer resection. J Clin Oncol. 2004;22:3255–3260
  4. Ahuja V, Coleman RE, Herndon J, Patz EF. The prognostic significance of fluorodeoxyglucose positron emission tomography imaging for patients with nonsmall cell lung carcinoma. Cancer. 1998;83:918–924
  5. Cerfolio RJ, Bryant AS, Ohja B, Bartolucci AA. The maximum standardized uptake values on positron emission tomography of a non-small cell lung cancer predict stage, recurrence, and survival. J Thorac Cardiovasc Surg. 2005;130:151–159
  6. Dhital K, Saunders CAB, Seed PT, O’Doherty MJ, Dussek J. 18F]Fluorodeoxyglucose positron emission tomography and its prognostic value in lung cancer. Eur J Cardiothorac Surg. 2000;18:425–428
  7. Higashi K, Ueda Y, Arisaka Y, Sakuma T, Nambu Y, Oguchi M, et al. 18F-FDG uptake as a biologic prognostic factor for recurrence in patients with surgically resection non-small cell lung cancer. J Nucl Med. 2002;43:39–45
  8. Jeong H-J, Min J-J, Park JM, Chung J-K, Kim BT, Jeong JM, et al. Determination of the prognostic value of [18F]fluorodeoxyglucose uptake by using positron emission tomography in patients with non-small cell lung cancer. Nucl Med Commun. 2002;23:865–870
  9. Kieninger AN, Welsh R, Bendick PJ, Zelenock G, Chmielewski GW. Positron-emission tomography as a prognostic tool for early-stage lung cancer. Am J Surg. 2006;191:433–436
  10. Port JL, Andrade RS, Levin MA, Korst RJ, Lee PC, Becker DE, et al. Positron emission tomographic scanning in the diagnosis and staging of non-small cell lung cancer 2 cm in size or less. J Thorac Cardiovasc Surg. 2005;130:1611–1615
  11. Sasaki R, Komaki R, Macapinlac H, Erasmus J, Allen P, Forster K, et al. [18F]fluorodeoxyglucose uptake by positron emission tomography predicts outcome of non-small-cell lung cancer. J Clin Oncol. 2005;23:1136–1143
  12. Vansteenkiste JF, Stroobants SG, Dupont PJ, De Leyn PR, Verbeken EK, Deneffe GJ, et al. Prognostic importance of the standardized uptake value on 18F-fluoro-2-deoxy-glucose-positron emission tomography scan in non-small-cell lung cancer: An analysis of 125 cases. J Clin Oncol. 1999;17:3201–3206
  13. Sugawara Y, Quint LE, Iannettoni MD, Orringer MB, Russo JE, Recker BE, et al. Does the FDG uptake of primary non-small cell lung cancer predict prognosis?: A work in progress. Clin Positron Imaging. 1999;2:111–118
  14. Vesselle H, Turcotte E, Wiens L, Schmidt R, Takasagui JE, Lalani T, et al. Relationship between non-small cell lung cancer fluorodeoxyglucose uptake at positron emission tomography and surgical stage with relevance to patient prognosis. Clin Cancer Res. 2004;10:4709–4716
  15. Borst GR, Belderbos JSA, Boellaard R, Comans EFI, De Jaeger K, Lammertsma AA, et al. Standardised FDG uptake: a prognostic factor for inoperable non-small cell lung cancer. Eur J Cancer. 2005;41:1533–1541
  16. Pillot G, Siegel BA, Govindan R. Prognostic value of fluorodeoxyglucose positron emission tomography in non-small cell lung cancer (A review). J Thorac Oncol. 2006;1:152–159
  17. Cerfolio RJ, Bryant AS, Ojha B, Eloubeidi M. Improving the inaccuracies of clinical staging of patients with NSLCC: a prospective trial. Ann Thorac Surg. 2005;80:1207–1213
  18. Roberts JR, Blum MG, Arildsen R, Drinkwater DC, Christian KR, Powers TA, et al. Prospective comparison of radiologic, thoracoscopic, and pathologic staging in patients with early non-small cell lung cancer. Ann Thorac Surg. 1999;68:1154–1158

PII: S0022-5223(07)00235-8

doi: 10.1016/j.jtcvs.2007.01.041

The Journal of Thoracic and Cardiovascular Surgery
Volume 133, Issue 6 , Pages 1419-1427.e4 , June 2007