The Journal of Thoracic and Cardiovascular Surgery
Volume 134, Issue 1 , Pages 74-81.e2 , July 2007

Early gene expression profiles during intraoperative myocardial ischemia-reperfusion in cardiac surgery

  • Sara Arab, PhD

      Affiliations

    • Hospital for Sick Children, Richard Lewar Centre of Excellence, Toronto General Hospital, University of Toronto, Toronto, Canada.
    • These authors contributed equally to this article.
    • ,
  • Igor E. Konstantinov, MD, PhD

      Affiliations

    • Division of Cardiovascular Surgery, Toronto General Hospital, University of Toronto, Toronto, Canada
    • These authors contributed equally to this article.
    • ,
  • Cathy Boscarino, MSc

      Affiliations

    • Division of Cardiovascular Surgery, Toronto General Hospital, University of Toronto, Toronto, Canada
    • ,
  • Eva Cukerman, BSc

      Affiliations

    • Hospital for Sick Children, Richard Lewar Centre of Excellence, Toronto General Hospital, University of Toronto, Toronto, Canada.
    • ,
  • Alessandro Mori, BSc

      Affiliations

    • Division of Cardiovascular Surgery, Toronto General Hospital, University of Toronto, Toronto, Canada
    • ,
  • Jia Li, MD, PhD

      Affiliations

    • Division of Cardiology, Toronto General Hospital, University of Toronto, Toronto, Canada
    • ,
  • Peter P. Liu, MD

      Affiliations

    • Hospital for Sick Children, Richard Lewar Centre of Excellence, Toronto General Hospital, University of Toronto, Toronto, Canada.
    • ,
  • Andrew N. Redington, MD

      Affiliations

    • Division of Cardiology, Toronto General Hospital, University of Toronto, Toronto, Canada
    • ,
  • John G. Coles, MD

      Affiliations

    • Division of Cardiovascular Surgery, Toronto General Hospital, University of Toronto, Toronto, Canada
    • These authors contributed equally to this article.
    • Corresponding Author InformationAddress for reprints: Dr John G. Coles, Division of Cardiovascular Surgery, Hospital for Sick Children, 555 University Avenue, Toronto, M5G 1X8, Canada.

Received 13 June 2006 ,Revised 2 January 2007 ,Accepted 8 January 2007.

References 

  1. Depre C, Tomlinson JE, Kudej RK, et al. Gene program for cardiac cell survival induced by transient ischemia in conscious pigs. Proc Natl Acad Sci U S A. 2001;98:9336–9341
  2. Lu L, Chen SS, Zhang JQ, et al. Activation of nuclear factor-kappaB and its proinflammatory mediator cascade in the infarcted rat heart. Biochem Biophys Res Commun. 2004;321:879–885
  3. Brazma A, Hingamp P, Quackenbush J, et al. Minimum information about a microarray experiment (MIAME)-toward standards for microarray data. Nat Genet. 2001;29:365–371
  4. Konstantinov IE, Arab S, Li J, et al. The remote ischemic preconditioning stimulus modifies gene expression in mouse myocardium. J Thorac Cardiovasc Surg. 2005;130:1326–1332
  5. Konstantinov IE, Arab S, Kharbanda RK, et al. The remote ischemic preconditioning stimulus modifies inflammatory gene expression in humans. Physiol Genomics. 2004;19:143–150
  6. Gibson UE, Heid CA, Williams PM. A novel method for real time quantitative RT-PCR. Genome Res. 1996;6:995–1001
  7. Fujioka S, Niu J, Schmidt C, et al. NF-kappaB and AP-1 connection: mechanism of NF-kappaB-dependent regulation of AP-1 activity. Mol Cell Biol. 2004;24:7806–7819
  8. Giannone G, Jiang G, Sutton DH, et al. Talin1 is critical for force-dependent reinforcement of initial integrin-cytoskeleton bonds but not tyrosine kinase activation. J Cell Biol. 2003;163:409–419
  9. Halestrap AP, Wang X, Poole RC, et al. Lactate transport in heart in relation to myocardial ischemia. Am J Cardiol. 1997;80:17A–25A
  10. Schurr A, Payne RS, Miller JJ, et al. Blockade of lactate transport exacerbates delayed neuronal damage in a rat model of cerebral ischemia. Brain Res. 2001;895:268–272
  11. Peterson KR. Hemoglobin switching: new insights. Curr Opin Hematol. 2003;10:123–129
  12. Simkhovich BZ, Marjoram P, Poizat C, et al. Brief episode of ischemia activates protective genetic program in rat heart: a gene chip study. Cardiovasc Res. 2003;59:450–459
  13. Hausenloy DJ, Yellon DM. New directions for protecting the heart against ischaemia-reperfusion injury: targeting the Reperfusion Injury Salvage Kinase (RISK)-pathway. Cardiovasc Res. 2004;61:448–460
  14. Davani EY, Brumme Z, Singhera GK, et al. Insulin-like growth factor-1 protects ischemic murine myocardium from ischemia/reperfusion associated injury. Crit Care. 2003;7:R176–R183
  15. Scheinowitz M, Kessler-Icekson G, Freimann S, et al. Short- and long-term swimming exercise training increases myocardial insulin-like growth factor-I gene expression. Growth Horm IGF Res. 2003;13:19–25
  16. Crackower MA, Oudit GY, Kozieradzki I, et al. Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathways. Cell. 2002;110:737–749
  17. Shioi T, Kang PM, Douglas PS, et al. The conserved phosphoinositide 3-kinase pathway determines heart size in mice. EMBO J. 2000;19:2537–2548
  18. McMullen JR, Shioi T, Huang WY, et al. The insulin-like growth factor 1 receptor induces physiological heart growth via the phosphoinositide 3-kinase(p110alpha) pathway. J Biol Chem. 2004;279:4782–4793
  19. Bellomo D, Headrick JP, Silins GU, et al. Mice lacking the vascular endothelial growth factor-B gene (Vegfb) have smaller hearts, dysfunctional coronary vasculature, and impaired recovery from cardiac ischemia. Circ Res. 2000;86:E29–E35
  20. Silvestre JS, Tamarat R, Ebrahimian TG, et al. Vascular endothelial growth factor-B promotes in vivo angiogenesis. Circ Res. 2003;93:114–123
  21. Arbibe L, Mira JP, Teusch N, et al. Toll-like receptor 2-mediated NF-kappa B activation requires a Rac1-dependent pathway. Nat Immunol. 2000;1:533–540
  22. Sizemore N, Lerner N, Dombrowski N, et al. Distinct roles of the Ikappa B kinase alpha and beta subunits in liberating nuclear factor kappa B (NF-kappa B) from Ikappa B and in phosphorylating the p65 subunit of NF-kappa B. J Biol Chem. 2002;277:3863–3869
  23. Teoh N, Leclercq I, Pena AD, et al. Low-dose TNF-alpha protects against hepatic ischemia-reperfusion injury in mice: implications for preconditioning. Hepatology. 2003;37:118–128
  24. Xuan YT, Tang XL, Banerjee S, et al. Nuclear factor-kappaB plays an essential role in the late phase of ischemic preconditioning in conscious rabbits. Circ Res. 1999;84:1095–1109
  25. Nelson SK, Wong GH, McCord JM. Leukemia inhibitory factor and tumor necrosis factor induce manganese superoxide dismutase and protect rabbit hearts from reperfusion injury. J Mol Cell Cardiol. 1995;27:223–229
  26. Hausenloy DJ, Tsang A, Mocanu MM, et al. Ischemic preconditioning protects by activating prosurvival kinases at reperfusion. Am J Physiol Heart Circ Physiol. 2005;288:H971–H976
  27. Wu C. ILK interactions. J Cell Sci. 2001;114(Pt 14):2549–2550
  28. Barandon L, Couffinhal T, Dufourcq P, et al. Frizzled A, a novel angiogenic factor: promises for cardiac repair. Eur J Cardiothorac Surg. 2004;25:76–83
  29. Barandon L, Couffinhal T, Ezan J, et al. Reduction of infarct size and prevention of cardiac rupture in transgenic mice overexpressing FrzA. Circulation. 2003;108:2282–2289
  30. Choi JH, Hur J, Yoon CH, et al. Augmentation of therapeutic angiogenesis using genetically modified human endothelial progenitor cells with altered glycogen synthase kinase-3beta activity. J Biol Chem. 2004;279:49430–49438
  31. Sato N, Meijer L, Skaltsounis L, et al. Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor. Nat Med. 2004;10:55–63
  32. Coles JG, Boscarino C, Takahashi M, et al. Cardioprotective stress response in the human fetal heart. J Thorac Cardiovasc Surg. 2005;129:1128–1136
  33. Membrillo-Hernandez J, Coopamah MD, Anjum MF, et al. The flavohemoglobin of Escherichia coli confers resistance to a nitrosating agent, a “nitric oxide releaser,” and paraquat and is essential for transcriptional responses to oxidative stress. J Biol Chem. 1999;274:748–754
  34. Okamoto M, Tsuchiya K, Kanematsu Y, et al. Nitrite-derived nitric oxide formation following ischemia-reperfusion injury in kidney. Am J Physiol Renal Physiol. 2005;288:F182–F187
  35. Canales RD, Luo Y, Willey JC, et al. Evaluation of DNA microarray results with quantitative gene expression platforms. Nat Biotechnol. 2006;24:1115–1116
  36. Lu H, Dai X, Du C, et al. Integrin-linked kinase (ILK) is upregulated in cardiac hypertrophy and causes hypertrophy in transgenic mice. Circulation. 2006;114:2271–2279
  37. Chen H, Shi S, Acosta L, et al. BMP10 is essential for maintaining cardiac growth during murine cardiogenesis. Development. 2004;131:2219–2231

PII: S0022-5223(07)00211-5

doi: 10.1016/j.jtcvs.2007.01.025

The Journal of Thoracic and Cardiovascular Surgery
Volume 134, Issue 1 , Pages 74-81.e2 , July 2007

Article Tools

* Image Usage & Resolution