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Volume 133, Issue 4 , Pages 880-887.e1 , April 2007

A randomized clinical trial of regional cerebral perfusion versus deep hypothermic circulatory arrest: Outcomes for infants with functional single ventricle

Read at the Eighty-sixth Annual Meeting of The American Association for Thoracic Surgery, Philadelphia, Pa, April 29-May 3, 2006.

Caren S. Goldberg, MD
- Division of Pediatric Cardiology, University of Michigan, Ann Arbor, Mich
- Address for reprints: Caren S. Goldberg, MD, C.S. Mott Children’s Hospital, L1221 Women’s Box 0204, 1500 East Medical Center Dr, Ann Arbor, MI 48109-0204.
Edward L. Bove, MD
- Section of Cardiac Surgery, University of Michigan, Ann Arbor, Mich
Eric J. Devaney, MD
- Section of Cardiac Surgery, University of Michigan, Ann Arbor, Mich
Eileen Mollen, PhD
- Division of Pediatric Psychology, University of Michigan, Ann Arbor, Mich
Edward Schwartz, PhD
- Division of Pediatric Psychology, University of Michigan, Ann Arbor, Mich
Shauna Tindall, PhD
- Division of Pediatric Psychology, University of Michigan, Ann Arbor, Mich
Cheryl Nowak, RN
- Section of Cardiac Surgery, University of Michigan, Ann Arbor, Mich
John Charpie, MD
- Division of Pediatric Cardiology, University of Michigan, Ann Arbor, Mich
Morton B. Brown, PhD
- School of Public Health, Department of Biostatistics, University of Michigan, Ann Arbor, Mich.
Tom J. Kulik, MD
- Division of Pediatric Cardiology, University of Michigan, Ann Arbor, Mich
Richard G. Ohye, MD
- Section of Cardiac Surgery, University of Michigan, Ann Arbor, Mich

Received 20 June 2006 ,Revised 8 November 2006 ,Accepted 20 November 2006.

llustration of RCP. Arrows represent flow of blood from cardiopulmonary bypass circuit through polytetrafluoroethylene graft anastomosed to the innominate artery. RCP, regional cerebral perfusion.

llustration of RCP. Arrows represent flow of blood from cardiopulmonary bypass circuit through polytetrafluoroethylene graft anastomosed to the innominate artery. RCP, regional cerebral perfusion.
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Survival for the RCP and DHCA treatment groups at hospital discharge after Norwood operation, to second-stage operation, and to 1 year of age. RCP, retrograde cerebral perfusion; DHCA, deep hypothermi

Survival for the RCP and DHCA treatment groups at hospital discharge after Norwood operation, to second-stage operation, and to 1 year of age. RCP, retrograde cerebral perfusion; DHCA, deep hypothermic circulatory arrest.
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PDI and MDI scores are plotted on the y-axis compared with MDI scores on the x-axis at pre–second stage (A) and at 1 year (B). PDI, Psychomotor Development Index; MDI, Mental Development Index.

PDI and MDI scores are plotted on the y-axis compared with MDI scores on the x-axis at pre–second stage (A) and at 1 year (B). PDI, Psychomotor Development Index; MDI, Mental Development Index.
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Box plots demonstrate comparison of DHCA and RCP groups for PDI pre–second stage (A), MDI pre–second stage (B), PDI at 1 year (C), and MDI at 1 year (D). DHCA, deep hypothermic circulatory arrest; RCP

Box plots demonstrate comparison of DHCA and RCP groups for PDI pre–second stage (A), MDI pre–second stage (B), PDI at 1 year (C), and MDI at 1 year (D). DHCA, deep hypothermic circulatory arrest; RCP, regional cerebral perfusion; PDI, Psychomotor Development Index; MDI, Mental Development Index.
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