The Journal of Thoracic and Cardiovascular Surgery
Volume 133, Issue 3 , Pages 599-600 , March 2007

Bone marrow cell therapy for heart disease: A few good men and women wanted

  • Shafie Fazel, MD, PhD

      Affiliations

    • Corresponding Author InformationAddress for reprints: Shafie Fazel, MD, PhD, 4N-466, Toronto General Hospital, 200 Elizabeth Street, Toronto, Ontario, Canada M5G-2C4.

Received 1 October 2006 ,Revised 14 October 2006 ,Accepted 25 October 2006.

References 

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  2. Orlic D, Kajstura J, Chimenti S, Jakoniuk I, Anderson SM, Li B, et al. Bone marrow cells regenerate infarcted myocardium. Nature. 2001;410:701–705
  3. Orlic D, Kajstura J, Chimenti S, Limana F, Jakoniuk I, Quaini F, et al. Mobilized bone marrow cells repair the infarcted heart, improving function and survival. Proc Natl Acad Sci U S A. 2001;98:10344–10349
  4. Fazel S, Tang GH, Angoulvant D, Cimini M, Weisel RD, Li RK, et al. Current status of cellular therapy for ischemic heart disease. Ann Thorac Surg. 2005;79(suppl):S2238–S2247
  5. Balsam LB, Wagers AJ, Christensen JL, Kofidis T, Weissman IL, Robbins RC. Haematopoietic stem cells adopt mature haematopoietic fates in ischaemic myocardium. Nature. 2004;428:668–673
  6. Murry CE, Soonpaa MH, Reinecke H, Nakajima H, Nakajima HO, Rubart M, et al. Haematopoietic stem cells do not transdifferentiate into cardiac myocytes in myocardial infarcts. Nature. 2004;428:664–668
  7. Nygren JM, Jovinge S, Breitbach M, Sawen P, Roll W, Hescheler J, et al. Bone marrow-derived hematopoietic cells generate cardiomyocytes at a low frequency through cell fusion, but not transdifferentiation. Nat Med. 2004;10:494–501
  8. Chien KR. Stem cells: lost in translation. Nature. 2004;428:607–608
  9. Fazel S, Cimini M, Chen L, Li S, Angoulvant D, Fedak P, et al. Cardioprotective c-kit+ cells are from the bone marrow and regulate the myocardial balance of angiogenic cytokines. J Clin Invest. 2006;116:1865–1877
  10. Stamm C, Westphal B, Kleine HD, Petzsch M, Kittner C, Klinge H, et al. Autologous bone-marrow stem-cell transplantation for myocardial regeneration. Lancet. 2003;361:45–46
  11. Yin AH, Miraglia S, Zanjani ED, Almeida-Porada G, Ogawa M, Leary AG, et al. AC133, a novel marker for human hematopoietic stem and progenitor cells. Blood. 1997;90:5002–5012

PII: S0022-5223(06)01961-1

doi: 10.1016/j.jtcvs.2006.10.029

The Journal of Thoracic and Cardiovascular Surgery
Volume 133, Issue 3 , Pages 599-600 , March 2007

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