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Volume 133, Issue 1 , Pages 58-64 , January 2007

Reverse right ventricular remodeling after pulmonary endarterectomy in patients with chronic thromboembolic pulmonary hypertension: Utility of magnetic resonance imaging to demonstrate restoration of the right ventricle

Herre J. Reesink, MD
- Department of Pulmonology of the Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
- Herre J. Reesink was supported by a grant from Actelion Pharmaceuticals Nederland bv, Woerden, The Netherlands.
J. Tim Marcus, PhD
- Department of Physics and Medical Technology of the Free University Medical Center, Amsterdam, The Netherlands
Igor I. Tulevski, MD, PhD
- Department of Cardiology of the Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
Stuart Jamieson, MD
- Department of Cardiothoracic Surgery of the University of California San Diego, San Diego, Calif.
Jaap J. Kloek, MD
- Department of Cardiothoracic Surgery of the Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
Anton Vonk Noordegraaf, MD, PhD
- Department of Pulmonology of the Free University Medical Center, Amsterdam, The Netherlands
Paul Bresser, MD, PhD
- Department of Pulmonology of the Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
- Address for reprints: P. Bresser, MD, PhD, Academic Medical Center, University of Amsterdam, Department of Pulmonology, F5-144, PO Box 22700, 1100 DE Amsterdam, the Netherlands.

Received 31 March 2006 ,Revised 14 August 2006 ,Accepted 11 September 2006.

RVEDV (A), RVESV (B), LVEDV (C), and LVESV (D) in patients with CTEPH (n = 17) before and after PEA compared with healthy controls (n = 12). Data are expressed as mean ± SEM. n.s., Not significant.

RVEDV (A), RVESV (B), LVEDV (C), and LVESV (D) in patients with CTEPH (n = 17) before and after PEA compared with healthy controls (n = 12). Data are expressed as mean ± SEM. n.s., Not significant.
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MRI short-axis cine images at basal (upper panel) and midventricular (lower panel) level, before (A) and after (B) PEA (relative time 55% in the cardiac cycle). Note the encroachment of the interventr

MRI short-axis cine images at basal (upper panel) and midventricular (lower panel) level, before (A) and after (B) PEA (relative time 55% in the cardiac cycle). Note the encroachment of the interventricular septum into the LV before PEA and the restoration of the septal bowing to normal after PEA. Note also the reversal of RV hypertrophy and the normalization of the RV and LV volumes.
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Correlation between RVEF (A), RV mass (B), and septal bowing (curvature: 1/R) (C) and the TPR in patients with CTEPH (n = 17) before PEA.

Correlation between RVEF (A), RV mass (B), and septal bowing (curvature: 1/R) (C) and the TPR in patients with CTEPH (n = 17) before PEA.
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RV (A, B) and LV mass (C) in patients with CTEPH (n = 17) before and after PEA compared with healthy controls (n = 12). Data are expressed as mean ± SEM.

RV (A, B) and LV mass (C) in patients with CTEPH (n = 17) before and after PEA compared with healthy controls (n = 12). Data are expressed as mean ± SEM.
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Septal bowing (curvature: 1/R) in patients with CTEPH (n = 17) before and after PEA compared with healthy controls (n = 12). Data are expressed as mean ± SEM.

Septal bowing (curvature: 1/R) in patients with CTEPH (n = 17) before and after PEA compared with healthy controls (n = 12). Data are expressed as mean ± SEM.
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