The Journal of Thoracic and Cardiovascular Surgery
Volume 133, Issue 2 , Pages 317-324.e1 , February 2007

T2N0M0 esophageal cancer

Presented at the Eighty-sixth Annual Meeting of The American Association for Thoracic Surgery, Philadelphia, Penn, April 29-May 3, 2006.

  • Thomas W. Rice, MD

      Affiliations

    • Center for Swallowing and Esophageal Disorders, Cleveland Clinic, Cleveland, Ohio.
    • Department of Thoracic and Cardiovascular Surgery, Cleveland Clinic, Cleveland, Ohio.
    • Corresponding Author InformationReprint requests: Thomas W. Rice, MD, Cleveland Clinic, 9500 Euclid Avenue/Desk F24, Cleveland, OH 44195.
    • ,
  • David P. Mason, MD

      Affiliations

    • Center for Swallowing and Esophageal Disorders, Cleveland Clinic, Cleveland, Ohio.
    • Department of Thoracic and Cardiovascular Surgery, Cleveland Clinic, Cleveland, Ohio.
    • ,
  • Sudish C. Murthy, MD, PhD

      Affiliations

    • Center for Swallowing and Esophageal Disorders, Cleveland Clinic, Cleveland, Ohio.
    • Department of Thoracic and Cardiovascular Surgery, Cleveland Clinic, Cleveland, Ohio.
    • ,
  • Gregory Zuccaro Jr, MD

      Affiliations

    • Center for Swallowing and Esophageal Disorders, Cleveland Clinic, Cleveland, Ohio.
    • Department of Gastroenterology, Cleveland Clinic, Cleveland, Ohio.
    • ,
  • David J. Adelstein, MD

      Affiliations

    • Center for Swallowing and Esophageal Disorders, Cleveland Clinic, Cleveland, Ohio.
    • Department of Solid Tumor Oncology, Cleveland Clinic, Cleveland, Ohio.
    • ,
  • Lisa A. Rybicki, MS

      Affiliations

    • Department of Quantitative Health Sciences, Cleveland Clinic, Cleveland, Ohio.
    • ,
  • Eugene H. Blackstone, MD

      Affiliations

    • Center for Swallowing and Esophageal Disorders, Cleveland Clinic, Cleveland, Ohio.
    • Department of Quantitative Health Sciences, Cleveland Clinic, Cleveland, Ohio.

Received 10 May 2006 ,Revised 10 August 2006 ,Accepted 5 September 2006.

  • Image Result

    Survival after surgery alone for esophageal cancer according to pTNM. Each step represents a death, and vertical ticks represent a censored patient.

    Survival after surgery alone for esophageal cancer according to pTNM. Each step represents a death, and vertical ticks represent a censored patient.

  • Image Result

    Comparison of survival after surgery alone in overstaged cT2N0M0 patients versus non-cT2N0M0 patients with Figure 1.

    Comparison of survival after surgery alone in overstaged cT2N0M0 patients versus non-cT2N0M0 patients with <pT2N0M0 cancers (propensity-matched surgery-alone patients). Format is as in Figure 1.

  • Image Result

    Comparison of survival after surgery alone in understaged cT2N0M0 patients versus non-cT2N0M0 patients with >pT2N0M0 cancers (propensity-matched surgery-alone patients). Format is as in Figure 1.

    Comparison of survival after surgery alone in understaged cT2N0M0 patients versus non-cT2N0M0 patients with >pT2N0M0 cancers (propensity-matched surgery-alone patients). Format is as in Figure 1.

  • Image Result

    Comparison of survival after surgery followed by adjuvant therapy in understaged cT2N0M0 patients versus non-cT2N0M0 patients with >pT2N0M0 cancers (propensity-matched similarly treated patients). For

    Comparison of survival after surgery followed by adjuvant therapy in understaged cT2N0M0 patients versus non-cT2N0M0 patients with >pT2N0M0 cancers (propensity-matched similarly treated patients). Format is as in Figure 1.

  • Image Result
    Comparison of survival after surgery alone versus surgery followed by adjuvant therapy in understaged cT2N0M0 patients. At 1 and 3 years, 4 and 2 patients remained at risk in the postoperative adjuvan

    Comparison of survival after surgery alone versus surgery followed by adjuvant therapy in understaged cT2N0M0 patients. At 1 and 3 years, 4 and 2 patients remained at risk in the postoperative adjuvant therapy group, with 68% confidence limits of 72% to 99% and 20% to 65% at these intervals, respectively. After surgery alone, 5 and 3 patients remained at risk, with confidence limits of 34% to 66% and 16% to 44% at 1 and 3 years, respectively. Format is as in Figure 1.

  • Image Result
    Comparison of survival after induction therapy followed by surgery versus surgery first in cT2N0M0 patients. At 1 and 3 years, 37 and 24 patients remained at risk in the surgery-first group, with 68%

    Comparison of survival after induction therapy followed by surgery versus surgery first in cT2N0M0 patients. At 1 and 3 years, 37 and 24 patients remained at risk in the surgery-first group, with 68% confidence limits of 84% to 73% and 47% to 61% at these intervals, respectively. After induction therapy, 4 patients and 1 patient remained at risk, with confidence limits of 32% to 68% and 1% to 24% at 1 and 3 years, respectively. Format is as in Figure 1.

  • Image Result
    Comparison of survival after surgery alone in overstaged cT2N0M0 patients versus non-cT2N0M0 patients with

    Comparison of survival after surgery alone in overstaged cT2N0M0 patients versus non-cT2N0M0 patients with <pT2N0M0 cancers (unmatched patients treated with surgery alone). Format is as in Figure 1.

  • Image Result
    Comparison of survival after surgery alone in understaged cT2N0M0 patients versus non-cT2N0M0 patients with >pT2N0M0 cancers (unmatched patients treated with surgery alone). Format is as in Figure 1.

    Comparison of survival after surgery alone in understaged cT2N0M0 patients versus non-cT2N0M0 patients with >pT2N0M0 cancers (unmatched patients treated with surgery alone). Format is as in Figure 1.

  • Image Result
    Comparison of survival after surgery followed by adjuvant therapy in understaged cT2N0M0 patients versus non-cT2N0M0 patients with >pT2N0M0 cancers (unmatched patients treated similarly). Format is as

    Comparison of survival after surgery followed by adjuvant therapy in understaged cT2N0M0 patients versus non-cT2N0M0 patients with >pT2N0M0 cancers (unmatched patients treated similarly). Format is as in Figure 1.

  • Image Result
    Survival in surgery-first cT2N0M0 patients versus patients with pT2N0M0 tumors. Format is as in Figure 1.

    Survival in surgery-first cT2N0M0 patients versus patients with pT2N0M0 tumors. Format is as in Figure 1.

PII: S0022-5223(06)01751-X

doi: 10.1016/j.jtcvs.2006.09.023

The Journal of Thoracic and Cardiovascular Surgery
Volume 133, Issue 2 , Pages 317-324.e1 , February 2007

Article Tools

* Image Usage & Resolution