The Journal of Thoracic and Cardiovascular Surgery
Volume 133, Issue 2 , Pages 309-316 , February 2007

Differential vascular growth in postpneumonectomy compensatory lung growth

  • Lucas G. Fernandez, MD, DSc

      Affiliations

    • Department of Surgery, University of Virginia Health System, Charlottesville, Va
    • ,
  • Timothy D. Le Cras, PhD

      Affiliations

    • Division of Pulmonary Biology, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio.
    • ,
  • Mirta Ruiz, MD

      Affiliations

    • Department of Medicine, University of Virginia Health System, Charlottesville, Va
    • ,
  • David K. Glover, PhD

      Affiliations

    • Department of Medicine, University of Virginia Health System, Charlottesville, Va
    • ,
  • Irving L. Kron, MD

      Affiliations

    • Department of Surgery, University of Virginia Health System, Charlottesville, Va
    • ,
  • Victor E. Laubach, PhD

      Affiliations

    • Department of Surgery, University of Virginia Health System, Charlottesville, Va
    • Corresponding Author InformationAddress for reprints: Victor E. Laubach, PhD, University of Virginia Health System, Department of Surgery, PO Box 801359, Charlottesville, VA 22908.

Received 13 June 2006 ,Revised 25 August 2006 ,Accepted 13 September 2006.

References 

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  2. Brody JS. Time course of and stimuli to compensatory growth of the lung after pneumonectomy. J Clin Invest. 1975;56:897–904
  3. Buhain WJ, Brody JS. Compensatory growth of the lung following pneumonectomy. J Appl Physiol. 1973;35:898–902
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  5. Kuboi S, Mizuuchi A, Mizuuchi T, Taguchi T, Thurlbeck WM, Kida K. DNA synthesis and related enzymes altered in compensatory lung growth in rats. Scand J Clin Lab Invest. 1992;52:707–715
  6. Rannels DE, White DM, Watkins CA. Rapidity of compensatory lung growth following pneumonectomy in adult rats. J Appl Physiol. 1979;46:326–333
  7. Sekhon HS, Thurlbeck WM. A comparative study of postpneumonectomy compensatory lung response in growing male and female rats. J Appl Physiol. 1992;73:446–451
  8. Le Cras TD, Fernandez LG, Pastura PA, Laubach VE. Vascular growth and remodeling in compensatory lung growth following right lobectomy. J Appl Physiol. 2005;98:1140–1148
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  12. Leuwerke SM, Kaza AK, Tribble CG, Kron IL, Laubach VE. Inhibition of compensatory lung growth in endothelial nitric oxide synthase-deficient mice. Am J Physiol Lung Cell Mol Physiol. 2002;282:L1272–L1278
  13. Kaza AK, Kron IL, Kern JA, Long SM, Fiser SM, Nguyen RP, et al. Retinoic acid enhances lung growth after pneumonectomy. Ann Thorac Surg. 2001;71:1645–1650
  14. Roman CD, Hanley GA, Beauchamp RD. Operative technique for safe pulmonary lobectomy in Sprague-Dawley rats. Contemp Top Lab Anim Sci. 2002;41:28–30
  15. Scherle W. A simple method for volumetry of organs in quantitative steorology. Mikroskopie. 1970;26:57–60
  16. Haapasalo HK, Sallinen PK, Helen PT, Rantala IS, Helin HJ, Isola JJ. Comparison of three quantitation methods for PCNA immunostaining: applicability and relation to survival in 83 astrocytic neoplasms. J Pathol. 1993;171:207–214
  17. Ravikumar P, Yilmaz C, Dane DM, Johnson RL, Estrera AS, Hsia CC. Regional lung growth following pneumonectomy assessed by computed tomography. J Appl Physiol. 2004;97:1567–1574
  18. Hsia CC, Wu EY, Wagner E, Weibel ER. Preventing mediastinal shift after pneumonectomy impairs regenerative alveolar tissue growth. Am J Physiol Lung Cell Mol Physiol. 2001;281:L1279–L1287
  19. Maxey TS, Fernandez LG, Reece TB, Keeling WB, Kron IL, Laubach VE. Endothelial nitric oxide synthase is essential for postpneumonectomy compensatory vasodilation. Ann Thorac Surg. 2006;81:1234–1238
  20. McBride JT, Kirchner KK, Russ G, Finkelstein J. Role of pulmonary blood flow in postpneumonectomy lung growth. J Appl Physiol. 1992;73:2448–2451
  21. Li D, Fernandez LG, Dodd-o J, Langer J, Wang D, Laubach VE. Upregulation of hypoxia-induced mitogenic factor in compensatory lung growth after pneumonectomy. Am J Respir Cell Mol Biol. 2005;32:185–191

 Supported by Virginia Thoracic Society Career Investigator Award CI-52-N (V.E.L.), National Institutes of Health (NIH) HL67780 (V.E.L.), NIH HL72894 (T.D.L.C.), and the American Lung Association Career Investigator Award CI-31-N (T.D.L.C.).

PII: S0022-5223(06)01689-8

doi: 10.1016/j.jtcvs.2006.09.003

The Journal of Thoracic and Cardiovascular Surgery
Volume 133, Issue 2 , Pages 309-316 , February 2007

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