The Journal of Thoracic and Cardiovascular Surgery
Volume 133, Issue 1 , Pages 29-36 , January 2007

Hemodilutional anemia impairs neurologic outcome after cardiopulmonary bypass in a piglet model

  • Takashi Miura, MD

      Affiliations

    • Department of Cardiovascular Surgery, Heart Institute of Japan
    • Corresponding Author InformationAddress for reprints: Takashi Miura, MD, Department of Cardiovascular Surgery, The Heart Institute of Japan, Tokyo Women’s Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo 162-8666, Japan
    • ,
  • Takahiko Sakamoto, MD

      Affiliations

    • Department of Cardiovascular Surgery, Heart Institute of Japan
    • ,
  • Makio Kobayashi, MD

      Affiliations

    • Department of Pathology, Tokyo Women’s Medical University, Tokyo, Japan.
    • ,
  • Toshiharu Shin’oka, MD

      Affiliations

    • Department of Cardiovascular Surgery, Heart Institute of Japan
    • ,
  • Hiromi Kurosawa, MD

      Affiliations

    • Department of Cardiovascular Surgery, Heart Institute of Japan

Received 1 January 2006 ,Revised 12 August 2006 ,Accepted 28 August 2006.

  • Image Result

    Changes in NIRS data. A, HbO2 signal. B, HHb signal. C, HbT signal. D, CytO2 signal. E, TOI. ANOVA, Analysis of variance; BL, baseline; CPB, cardiopulmonary bypass; HbO2, oxygenated hemoglobin; HHb, d

    Changes in NIRS data. A, HbO2 signal. B, HHb signal. C, HbT signal. D, CytO2 signal. E, TOI. ANOVA, Analysis of variance; BL, baseline; CPB, cardiopulmonary bypass; HbO2, oxygenated hemoglobin; HHb, deoxygenated hemoglobin; HbT, total hemoglobin; CytO2, oxidized cytochrome a, a3; TOI, tissue oxygenation index; DPF, differential pathlength factor.

  • Image Result
    A, Results of histologic scores. Mann–Whitney U test revealed differences in hippocampus and total histologic score. B, Histology from hippocampus, paraffin section, hematoxylin-eosin stain. a. Grade

    A, Results of histologic scores. Mann–Whitney U test revealed differences in hippocampus and total histologic score. B, Histology from hippocampus, paraffin section, hematoxylin-eosin stain. a. Grade 0, showing no damage from group H (×20). b. Grade 3, showing hypoxic-ischemic injury from group L (×20). This is the most severely injured animal in this group. This would be scored as having a 3+ lesion. Note several neurons with hypereosinophilic cytoplasm and karyorrhectic nuclei (arrows).

PII: S0022-5223(06)01599-6

doi: 10.1016/j.jtcvs.2006.08.048

The Journal of Thoracic and Cardiovascular Surgery
Volume 133, Issue 1 , Pages 29-36 , January 2007

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