The Journal of Thoracic and Cardiovascular Surgery
Volume 133, Issue 1 , Pages 21-28.e4 , January 2007

Hemodynamic effects of partial ventricular support in chronic heart failure: Results of simulation validated with in vivo data

  • Deborah Morley, PhD

      Affiliations

    • Department of Clinical Affairs, CircuLite, Inc, Hackensack, NJ
    • Corresponding Author InformationAddress for reprints: Deborah Morley, PhD, CircuLite, Inc, Clinical and Regulatory, 401 Hackensack Ave, Hackensack, NJ 07601
    • ,
  • Kenneth Litwak, DVM, PhD

      Affiliations

    • Department of Surgery, University of Louisville, Louisville, Kentucky
    • ,
  • Paul Ferber, BS

      Affiliations

    • Center for New Media Teaching and Learning, Columbia University, New York, NY
    • ,
  • Paul Spence, MD

      Affiliations

    • Louisville, Ky
    • ,
  • Robert Dowling, MD

      Affiliations

    • Department of Surgery, University of Louisville, Louisville, Kentucky
    • ,
  • Bart Meyns, MD, PhD

      Affiliations

    • Department of Surgery, University of Leuven, Leuven, Belgium
    • ,
  • Bartley Griffith, MD

      Affiliations

    • Department of Surgery, University of Maryland, Baltimore, Maryland
    • ,
  • Daniel Burkhoff, MD, PhD

      Affiliations

    • Center for New Media Teaching and Learning, Columbia University, New York, NY
    • Cardiovascular Research Foundation, Orangeburg, NY

Received 22 November 2005 ,Revised 9 June 2006 ,Accepted 7 July 2006.

References 

  1. Mancini D, Burkhoff D. Mechanical device-based methods of managing and treating heart failure. Circulation. 2005;112:438–448
  2. Burkhoff D, Holmes JW, Madigan J, Barbone A, Oz MC. Left ventricular assist device-induced reverse ventricular remodeling. Prog Cardiovasc Dis. 2000;43:19–26
  3. Abraham WT, Fisher WG, Smith AL, Delurgio DB, Leon AR, Loh E, et al. Cardiac resynchronization in chronic heart failure. N Engl J Med. 2002;346:1845–1853
  4. Bristow MR, Feldman AM, Saxon LA. Heart failure management using implantable devices for ventricular resynchronization: Comparison of Medical Therapy, Pacing, and Defibrillation in Chronic Heart Failure (COMPANION) trial (COMPANION Steering Committee and COMPANION Clinical Investigators [In Process Citation]). J Card Fail. 2000;6:276–285
  5. Packer M, Bristow MR, Cohn JN, Colucci WS, Fowler MB, Gilbert EM, et al. U.S. Carvedilol Heart Failure Study Group The effect of carvedilol on morbidity and mortality in patients with chronic heart failure. N Engl J Med. 1996;334:1349–1355
  6. Packer M, Coats AJ, Fowler MB, Katus HA, Krum H, Mohacsi P, et al. Effect of carvedilol on survival in severe chronic heart failure. N Engl J Med. 2001;344:1651–1658
  7. Burkhoff D, Dickstein M, Ferber P. The heart simulator. Available at: http://www.columbia.edu/itc/hs/medical/heartsim/. Accessed 2005.
  8. Burkhoff D, Tyberg JV. Why does pulmonary venous pressure rise following the onset of left ventricular dysfunction: a theoretical analysis. Am J Physiol Heart Circ Physiol. 1993;265:H1819–H1828
  9. Santamore WP, Burkhoff D. Hemodynamic consequences of ventricular interaction as assessed by model analysis. Am J Physiol Heart Circ Physiol. 1991;260:H146–H157
  10. Dickstein ML, Burkhoff D. A theoretical analysis of the effect of pulmonary vasodilation on pulmonary venous pressure: implications for inhaled nitric oxide therapy. J Heart Lung Transplant. 1996;15:715–721
  11. Dickstein ML, Spotnitz HM, Rose EA, Burkhoff D. Heart reduction surgery: an analysis of the impact on cardiac function. J Thorac Cardiovasc Surg. 1997;113:1032–1040
  12. Artrip JH, Oz M, Burkhoff D. Left ventricular volume reduction surgery for heart failure: a physiologic perspective. J Thorac Cardiovasc Surg. 2001;122:775–782
  13. Schima H, Vollkron M, Boehm H, Rothy W, Haisjackl M, Wieselthaler G, et al. Weaning of rotary blood pump recipients after myocardial recovery: a computer study of changes in cardiac energetics. J Thorac Cardiovasc Surg. 2004;127:1743–1750
  14. Litwak KN, McMahan A, Lott KA, Lott LE, Koenig SC. Monensin toxicosis in the domestic bovine calf: a large animal model of cardiac dysfunction. Contemp Top Lab Anim Sci. 2005;44:45–49
  15. Suga H. Ventricular energetics. Physiol Rev. 1990;70:247–277

 The study was supported by a grant from CircuLite, Inc. Deborah Morley reports CircuLite employment and stock options. Kenneth Litwak reports CircuLite consulting fees. Paul Ferber Reports Atria Medical, CircuLite, Dupont, and Transoma consulting fees. Paul Spence reports CircuLite consulting fees, equity, and patents. Robert Dowling reports CircuLite consulting fees. Bart Meyns reports Abiomed lecture fees, CircuLite consulting fees and equity, and grant support from Abiomed and CircuLite. Bartley Griffith reports WorldHeart consultant fees. Daniel Burkhoff reports Accelerated Technologies and Impulse Dynamics consulting fees; Abiomed, CircuLite, and Impulse Dynamics equity; and grant support from CircuLite. All of the companies listed have direct or indirect commercial interests in implantable cardiac assist devices.

PII: S0022-5223(06)01572-8

doi: 10.1016/j.jtcvs.2006.07.037

The Journal of Thoracic and Cardiovascular Surgery
Volume 133, Issue 1 , Pages 21-28.e4 , January 2007

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