« Previous
Next »
The Journal of Thoracic and Cardiovascular Surgery
Volume 133, Issue 1
, Pages 13-20.e1
, January 2007
Increased cerebral and renal endothelial nitric oxide synthase gene expression after cardiopulmonary bypass in the rat
References
- Longitudinal assessment of neurocognitive function after coronary-artery bypass surgery. N Engl J Med. 2001;344:395–402
- Hemodilution during cardiopulmonary bypass is an independent risk factor for acute renal failure in adult cardiac surgery. J Thorac Cardiovasc Surg. 2005;129:391–400
- Association of genetic polymorphisms with risk of renal injury after coronary bypass graft surgery. Am J Kidney Dis. 2005;45:519–530
- . The association of lowest hematocrit during cardiopulmonary bypass with acute renal injury after coronary artery bypass surgery. Ann Thorac Surg. 2003;76:784–791
- . Adverse effects of low hematocrit during cardiopulmonary bypass in the adult: should current practice be changed?. J Thorac Cardiovasc Surg. 2003;125:1438–1450
- The influence of hemodilution on outcome after hypothermic cardiopulmonary bypass: results of a randomized trial in infants. J Thorac Cardiovasc Surg. 2003;126:1765–1774
- . Renal medullary hypoxia during experimental cardiopulmonary bypass: a pilot study. Perfusion. 2005;20:53–58
- . The effect of leucocyte-depleting arterial line filters on cerebral microemboli and neuropsychological outcome following coronary artery bypass surgery. Eur J Cardiothorac Surg. 2004;25:267–274
- . Xenon attenuates cardiopulmonary bypass–induced neurologic and neurocognitive dysfunction in the rat. Anesthesiology. 2003;98:690–698
- . Differential cerebral gene expression during cardiopulmonary bypass in the rat: evidence for apoptosis?. Anesth Analg. 2002;94:1389–1394table
- Cerebral hypoxia during cardiopulmonary bypass: a magnetic resonance imaging study. Ann Thorac Surg. 1997;64:695–701
- . Decrease in jugular venous oxygen saturation during normothermic cardiopulmonary bypass predicts short-term postoperative neurologic dysfunction in elderly patients. J Am Coll Cardiol. 2001;38:1450–1455
- . Hemodilution during cardiopulmonary bypass increases cerebral infarct volume after middle cerebral artery occlusion in rats. Anesth Analg. 2004;99:974–981
- . Cardiovascular and renal control in NOS-deficient mouse models. Am J Physiol Regul Integr Comp Physiol. 2003;284:R628–R638
- . 7-Nitroindazole impedes erythrocyte flow response to isovolemic hemodilution in the cerebral capillary circulation. J Cereb Blood Flow Metab. 2000;20:220–224
- Nitric oxide production affects cerebral perfusion and metabolism after deep hypothermic circulatory arrest. Ann Thorac Surg. 1996;61:1699–1707
- . Cerebral response to haemodilution during cardiopulmonary bypass in dogs: the role of nitric oxide synthase. Br J Anaesth. 1999;82:237–243
- Differential cardiac gene expression during cardiopulmonary bypass: ischemia-independent upregulation of proinflammatory genes. J Thorac Cardiovasc Surg. 2005;130:330–339
- Fractal or biologically variable delivery of cardioplegic solution prevents diastolic dysfunction after cardiopulmonary bypass. J Thorac Cardiovasc Surg. 2002;123:63–71
- Shear stress stimulates phosphorylation of eNOS at Ser(635) by a protein kinase A–dependent mechanism. Am J Physiol Heart Circ Physiol. 2002;283:H1819–H1828
- Intracarotid infusion of the nitric oxide synthase inhibitor, l-NMMA, modestly decreases cerebral blood flow in human subjects. Anesthesiology. 2000;93:699–707
- . Nitric oxide synthase inhibition depresses the height of the cerebral blood flow-pressure autoregulation curve during moderate hypotension. J Cereb Blood Flow Metab. 2003;23:1085–1095
- . Inducible nitric oxide production is an adaptation to cardiopulmonary bypass–induced inflammatory response. Ann Thorac Surg. 2001;72:149–155
- . Nitric oxide: an endogenous modulator of leukocyte adhesion. Proc Natl Acad Sci U S A. 1991;88:4651–4655
- . An l-arginine/nitric oxide pathway present in human platelets regulates aggregation. Proc Natl Acad Sci U S A. 1990;87:5193–5197
- Cardiac surgery increases the activity of matrix metalloproteinases and nitric oxide synthase in human hearts. J Thorac Cardiovasc Surg. 2001;122:746–752
- Ischemia increases detectable endothelial nitric oxide synthase in rat and human myocardium. Nitric Oxide. 2001;5:317–333
- G894T polymorphism in the endothelial nitric oxide synthase gene is associated with an enhanced vascular responsiveness to phenylephrine. Circulation. 1999;99:3096–3098
- . Regulation of cerebellar nitric oxide production in response to prolonged in vivo hypoxia. J Neurosci Res. 1997;49:89–97
- . Prolonged hypoxia increases vascular endothelial growth factor mRNA and protein in adult mouse brain. J Appl Physiol. 1999;86:260–264
- Brain expression of inducible cyclooxygenase 2 messenger RNA in rats undergoing cardiopulmonary bypass. Anesthesiology. 2001;95:1380–1388
- In vivo expression profile of an endothelial nitric oxide synthase promoter-reporter transgene. Am J Physiol Heart Circ Physiol. 2000;278:H1352–H1361
- . Regulation of intrarenal blood flow in experimental heart failure: role of endothelin and nitric oxide. Am J Physiol. 1998;274:F766–F774
This work is attributed to the Department of Anesthesia, St Michael’s Hospital, University of Toronto.Supported by St Michael’s Hospital, Anemia Institute for Research and Education, Physicians’ Services Incorporated Foundation, Canadian Anesthesiologists’ Society. Dr Hare is a recipient of the Bristol-Myers Squibb-Canadian Anesthesiologists’ Society Career Scientist Award.
PII: S0022-5223(06)01568-6
doi: 10.1016/j.jtcvs.2006.06.047
© 2007 The American Association for Thoracic Surgery. Published by Elsevier Inc. All rights reserved.
« Previous
Next »
The Journal of Thoracic and Cardiovascular Surgery
Volume 133, Issue 1
, Pages 13-20.e1
, January 2007
