The Journal of Thoracic and Cardiovascular Surgery
Volume 133, Issue 1 , Pages 7-12 , January 2007

Effect of intravenous N-acetylcysteine on outcomes after coronary artery bypass surgery: A randomized, double-blind, placebo-controlled clinical trial

Received 8 June 2005 ,Revised 25 April 2006 ,Accepted 24 May 2006.

References 

  1. Tepel M, Van der Giet M, Schwarzfeld C, Laufer U, Liermann D, Zidek W. Prevention of radiographic-contrast-agent-induced reductions in renal function by acetylcysteine. N Engl J Med. 2000;343:180–184
  2. Sochman J. N-acetylcysteine in acute cardiology: 10 years later. J Am Coll Cardiol. 2002;39:1422–1428
  3. Tossios P, Bloch W, Huebner A, Raji MR, Dodos F, Klass O, et al. N-acetylcysteine prevents reactive oxygen species–mediated myocardial stress in patients undergoing cardiac surgery: results of a randomized, double-blind, placebo-controlled trial. J Thorac Cardiovasc Surg. 2003;126:1513–1520
  4. Fischer UM, Cox CS, Allen SJ, Stewart RH, Mehlhorn U, Laine GA. The antioxidant N-acetylcysteine preserves myocardial function and diminishes oxidative stress after cardioplegic arrest. J Thorac Cardiovasc Surg. 2003;126:1483–1488
  5. Andersen LW, Thilis J, Kharazmi A, Rygg I. The role of N-acetylcystein administration on the oxidative response of neutrophils during cardiopulmonary bypass. Perfusion. 1995;10:21–26
  6. Royston D, Bidstrup BP, Taylor KM, Sapsford RN. Effect of aprotinin on need for blood transfusion after repeat open-heart surgery. Lancet. 1987;2:1289–1291
  7. Dagenais F, Pelletier LC, Carrier M. Antegrade/retrograde cardioplegia for valve replacement: a prospective study. Ann Thorac Surg. 1999;68:1681–1685
  8. Pelletier LC, Carrier M, Leclerc Y, Cartier R, Wesolowska E, Solymoss BC. Intermittent antegrade warm versus cold blood cardioplegia: a prospective randomized study. Ann Thorac Surg. 1994;58:41–49
  9. Carrier M, Pellerin M, Perrault LP, Bouchard D, Page P, Searle N, et al. Cardioplegic arrest with l-arginine improves myocardial pretection: results of a prospective randomized clinical trial. Ann Thorac Surg. 2002;73:837–842
  10. Westhuyzen J, Cochrane AD, Tesar PJ, Mau T, Cross DB, Frenneaux MP, et al. Effect of preoperative supplementation with alpha-tocopherol and ascorbic acid on myocardial injury in patients undergoing cardiac operations. J Thorac Cardiovasc Surg. 1997;113:942–948
  11. Coghlan JG, Flitter WD, Clutton SM, Panda R, Daly R, Wright G, et al. Allopurinol pretreatment improves postoperative recovery and reduces lipid peroxidation in patients undergoing coronary artery bypass grafting. J Thorac Cardiovasc Surg. 1994;107:248–256
  12. Menasché P, Grousset C, Gauduel Y, Mouas C, Piwnica A. Maintenance of the myocardial thiol pool by N-acetylcysteine: an effective means of improving cardioplegic protection. J Thorac Cardiovasc Surg. 1992;103:936–943
  13. Fischer UM, Tossios P, Huebner A, Geissler HJ, Bloch W, Mehlhorn U. Myocardial apoptosis prevention by radical scavenging in patients undergoing cardiac surgery. J Thorac Cardiovasc Surg. 2004;128:103–108
  14. De Becker WA, Amsel B, Jorens PG, Bossaert L, Hiemstra PS, van Noort P, et al. N-acetylcysteine pretreatment of cardiac surgery patients influences plasma neutrophil elastase and neutrophil influx in bronchoalveolar lavage fluid. Intensive Care Med. 1996;22:900–908
  15. Sucu N, Cinel I, Unlu A, Aytacoglu B, Tamer L, Kocak Z, et al. N-acetylcysteine for preventing pump-induced oxidoinflammatory response during cardiopulmonary bypass. Surg Today. 2004;34:237–242
  16. Bergstroem L, Kagedal B, Paulsen O. Pharmacokinetics of N-acetylcysteine in man. Eur J Clin Pharmacol. 1986;31:217–222
  17. Chertow GM, Lazarus JM, Christiansen CL, Cook EF, Hammermeister KE, Grover F, et al. Perioperative renal risk stratification. Circulation. 1997;95:878–884
  18. Mangano CM, Diamonstone LS, Ramsay JG, Aggarwal A, Herskowitz A, Mangano DT The Multicenter Study of Perioperative Ischemia Research Group. Renal dysfunction after myocardial revascularization: risk factors, adverse outcomes, and hospital resource utilization. Ann Intern Med. 1998;128:194–203
  19. Burns KE, Chu MW, Novick RJ, Fox SA, Gallo K, Martin CM, et al. Perioperative N-acetylcysteine to prevent renal dysfunction in high-risk patients undergoing CABG surgery: a randomized controlled trial. JAMA. 2005;294:342–350

PII: S0022-5223(06)01566-2

doi: 10.1016/j.jtcvs.2006.05.070

The Journal of Thoracic and Cardiovascular Surgery
Volume 133, Issue 1 , Pages 7-12 , January 2007

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