The Journal of Thoracic and Cardiovascular Surgery
Volume 127, Issue 2 , Pages 365-375 , February 2004

Potentiation of paclitaxel cytotoxicity in lung and esophageal cancer cells by pharmacologic inhibition of the phosphoinositide 3-kinase/protein kinase B (Akt)–mediated signaling pathway

Read at the Eighty-third Annual Meeting of The American Association for Thoracic Surgery, Boston, Mass, May 4-7, 2003.

  • Dao M Nguyen, MD, MSc, FRCSC, FACS

      Affiliations

    • Section of Thoracic Oncology, Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Md, USA
    • Corresponding Author InformationAddress for reprints: Dao M. Nguyen, MD, MSc, FRCSC, FACS, Section of Thoracic Oncology, Room 2B07, Building 10, 10 Center Drive, Bethesda, MD, USA
    • ,
  • G.Aaron Chen, MS

      Affiliations

    • Section of Thoracic Oncology, Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Md, USA
    • ,
  • Rishindra Reddy, MD

      Affiliations

    • Section of Thoracic Oncology, Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Md, USA
    • ,
  • Wilson Tsai, MD

      Affiliations

    • Section of Thoracic Oncology, Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Md, USA
    • ,
  • William D Schrump

      Affiliations

    • Section of Thoracic Oncology, Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Md, USA
    • ,
  • George Cole Jr, MD

      Affiliations

    • Section of Thoracic Oncology, Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Md, USA
    • ,
  • David S Schrump, MD, FACS

      Affiliations

    • Section of Thoracic Oncology, Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Md, USA

Received 2 May 2003 ,Revised 28 August 2003 ,Accepted 9 September 2003.

References 

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  10. Pierce JW, Schoenleber R, Jesmok G, Best J, Moore SA, Collins T, et al.  Novel inhibitors of cytokine-induced IkappaBalpha phosphorylation and endothelial cell adhesion molecule expression show anti-inflammatory effects in vivo. J Biol Chem. 1997;272:21096–21103
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  13. Sizemore N, Lerner N, Dombrowski N, Sakurai H, Stark GR. Distinct roles of the Ikappa B kinase alpha and beta subunits in liberating nuclear factor kappa B (NF-kappa B) from Ikappa B and in phosphorylating the p65 subunit of NF-kappa B. J Biol Chem. 2002;277:3863–3869
  14. Romashkova JA, Makarov SS. NF-kappaB is a target of AKT in anti-apoptotic PDGF signaling. Nature. 1999;401:86–90
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  16. Datta SR, Dudek H, Tao X, Masters S, Fu H, Gotoh Y, et al.  Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell. 1997;91:231–241
  17. Cardone MH, Roy N, Stennicke HR, Salvesen GS, Franke TF, Stanbridge E, et al.  Regulation of cell death protease caspase-9 by phosphorylation. Science. 1998;282:1318–1321
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PII: S0022-5223(03)01793-8

doi: 10.1016/j.jtcvs.2003.09.033

The Journal of Thoracic and Cardiovascular Surgery
Volume 127, Issue 2 , Pages 365-375 , February 2004

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