The Journal of Thoracic and Cardiovascular Surgery
Volume 127, Issue 2 , Pages 335-343 , February 2004

Bronchoscopic surfactant administration preserves gas exchange and pulmonary compliance after single lung transplantation in dogs

  • Ivar Friedrich, MD

      Affiliations

    • Department of Cardiothoracic Surgery, Martin Luther University, Halle, Germany
    • Corresponding Author InformationAddress for reprints: Dr Ivar Friedrich, Department of Cardiothoracic Surgery, Martin Luther University, Ernst Grube Str 40, D-06097 Halle, Germany
    • ,
  • Jochen Börgermann, MD

      Affiliations

    • Department of Cardiothoracic Surgery, Martin Luther University, Halle, Germany
    • ,
  • Fred H Splittgerber, MD

      Affiliations

    • Department of Thoracic and Cardiovascular Surgery, University Essen, Essen, Germany
    • ,
  • Matthias Brinkmann, MD

      Affiliations

    • Department of Thoracic and Cardiovascular Surgery, University Essen, Essen, Germany
    • ,
  • J.Christoph Reidemeister, MD

      Affiliations

    • Department of Thoracic and Cardiovascular Surgery, University Essen, Essen, Germany
    • ,
  • Rolf E Silber, MD

      Affiliations

    • Department of Cardiothoracic Surgery, Martin Luther University, Halle, Germany
    • ,
  • Werner Seeger, MD

      Affiliations

    • Department of Internal Medicine, Justus Liebig University, Giessen, Germany
    • ,
  • Reinhold Schmidt, PhD

      Affiliations

    • Department of Internal Medicine, Justus Liebig University, Giessen, Germany
    • ,
  • Andreas Günther, MD

      Affiliations

    • Department of Internal Medicine, Justus Liebig University, Giessen, Germany

Received 12 August 2002 ,Revised 27 September 2002 ,Accepted 18 October 2002.

References 

  1. Khan SU, Salloum J, O'Donovan PB, et al.  Acute pulmonary edema after lung transplantation (the pulmonary reimplantation response). Chest. 1999;116:187–194
  2. Gregory TJ, Steinberg KP, Spragg R, et al.  Bovine surfactant therapy for patients with acute respiratory distress syndrome. Am J Respir Crit Care Med. 1997;155:1309–1315
  3. Novick RJ, Possmayer F, Veldhuizen RA, Menkis AH, McKenzie FN. Surfactant analysis and replacement therapy (a future tool of the lung transplant surgeon?). Ann Thorac Surg. 1991;52:1194–1200
  4. Erasmus ME, Petersen AH, Hofstede G, Haagsman HP, Bambang Oetomo S, Prop J. Surfactant treatment before reperfusion improves the immediate function of lung transplants in rats. Am J Respir Crit Care Med. 1996;153:665–670
  5. Novick RJ, Veldhuizen RA, Possmayer F, Lee J, Sandler D, Lewis JF. Exogenous surfactant therapy in thirty-eight hour lung graft preservation for transplantation. J Thorac Cardiovasc Surg. 1994;108:259–268
  6. Novick RJ, Gehman KE, Ali IS, Lee J. Lung preservation (the importance of endothelial and alveolar type II cell integrity). Ann Thorac Surg. 1996;62:302–314
  7. Novick RJ, Gilpin AA, Gehman KE, et al.  Mitigation of injury in canine lung grafts by exogenous surfactant therapy. J Thorac Cardiovasc Surg. 1997;113:342–353
  8. Hohlfeld JM, Struber M, Ahlf K, et al.  Exogenous surfactant improves survival and surfactant function in ischaemia-reperfusion injury in minipigs. Eur Respir J. 1999;13:1037–1043
  9. Nonaka M, Kadokura M, Takaba T. Effects of initial low flow reperfusion and surfactant administration on the viability of perfused cadaveric rat lungs. Lung. 1999;177:37–43
  10. Günther A, Balser M, Schmidt R, Markart P, Olk A, Börgermann J, et al.  Surfactant abnormalities after single lung transplantation in dogs: impact of bronchoscopic surfactant administration. J Thorac Cardiovasc Surg. 2004;127:344–354
  11. Ito Y, Veldhuizen RA, Yao LJ, McCaig LA, Bartlett AJ, Lewis JF. Ventilation strategies affect surfactant aggregate conversion in acute lung injury. Am J Respir Crit Care Med. 1997;155:493–499
  12. Neumann P. Extravascular lung water and intrathoracic blood volume (double versus single indicator dilution technique). Intensive Care Med. 1999;25:216–219
  13. Gunther A, Siebert C, Schmidt R, et al.  Surfactant alterations in severe pneumonia, acute respiratory distress syndrome, and cardiogenic lung edema. Am J Respir Crit Care Med. 1996;153:176–184
  14. Novick RJ, MacDonald J, Veldhuizen RA, et al.  Evaluation of surfactant treatment strategies after prolonged graft storage in lung transplantation. Am J Respir Crit Care Med. 1996;154:98–104
  15. Veldhuizen RA, Lee J, Sandler D, et al.  Alterations in pulmonary surfactant composition and activity after experimental lung transplantation. Am Rev Respir Dis. 1993;148:208–215
  16. Kemming GI, Merkel MJ, Schallerer A, et al.  Inhaled nitric oxide (NO) for the treatment of early allograft failure after lung transplantation. Munich Lung Transplant Group. Intensive Care Med. 1998;24:1173–1180
  17. Brinkmann M, Borgermann J, Splittgerber FH, et al.  Pulmonary blood flow is inhomogeneously reduced after Euro Collins-preservation and lung transplantation. Ann Thorac Surg. 2002;73:226–232
  18. Hayakawa H, Myrvik QN, St Clair RW. Pulmonary surfactant inhibits priming of rabbit alveolar macrophage. Evidence that surfactant suppresses the oxidative burst of alveolar macrophage in infant rabbits. Am Rev Respir Dis. 1989;140:1390–1397
  19. Kremlev SG, Umstead TM, Phelps DS. Effects of surfactant protein A and surfactant lipids on lymphocyte proliferation in vitro. Am J Physiol. 1994;267:L357–364
  20. Watanabe A, Kawaharada N, Kusajima K, Komatsu S, Takahashi H. Contralateral lung injury associated with single-lung ischemia-reperfusion injury. Ann Thorac Surg. 1996;62:1644–1649
  21. Hausen B, Rohde R, Hewitt CW, et al.  Exogenous surfactant treatment before and after sixteen hours of ischemia in experimental lung transplantation. J Thorac Cardiovasc Surg. 1997;113:1050–1058
  22. ARDS-Network-2000 . Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. The Acute Respiratory Distress Syndrome Network. N Engl J Med. 2000;342:1301–1308
  23. Slutsky AS. Lung injury caused by mechanical ventilation. Chest. 1999;116:9S–15S

☆ The study was supported by the Hans und Gertie Fischer Stiftung für Herz- und Kreislaufforschung (Mühlheim/Ruhr, Germany).

PII: S0022-5223(03)01575-7

doi: 10.1016/j.jtcvs.2002.10.001

The Journal of Thoracic and Cardiovascular Surgery
Volume 127, Issue 2 , Pages 335-343 , February 2004

Article Tools

* Image Usage & Resolution