The Journal of Thoracic and Cardiovascular Surgery
Volume 127, Issue 2 , Pages 329-334 , February 2004

Slow release of bone morphogenetic protein 2 from a gelatin sponge to promote regeneration of tracheal cartilage in a canine model

  • Taku Okamoto, MD

      Affiliations

    • Second Department of Surgery, Kagawa Medical University, Kagawa, Japan
    • ,
  • Yasumichi Yamamoto, MD

      Affiliations

    • Second Department of Surgery, Kagawa Medical University, Kagawa, Japan
    • ,
  • Masashi Gotoh, MD

      Affiliations

    • Second Department of Surgery, Kagawa Medical University, Kagawa, Japan
    • ,
  • Cheng-Long Huang, MD

      Affiliations

    • Second Department of Surgery, Kagawa Medical University, Kagawa, Japan
    • ,
  • Tatsuo Nakamura, MD

      Affiliations

    • Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan
    • ,
  • Yasuhiko Shimizu, MD

      Affiliations

    • Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan
    • ,
  • Yasuhiko Tabata, PhD

      Affiliations

    • Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan
    • ,
  • Hiroyasu Yokomise, MD

      Affiliations

    • Second Department of Surgery, Kagawa Medical University, Kagawa, Japan
    • Corresponding Author InformationAddress for correspondence: Hiroyasu Yokomise, MD, Second Department of Surgery, Kagawa Medical University, 1750-1, Ikenobe, Miki-cho, Kita-gun, Kagawa 761-0793, Japan

Received 28 May 2003 ,Revised 11 August 2003 ,Accepted 19 August 2003.

References 

  1. Hanawa T, Ikeda S, Funatsu T, Matsubara Y, Hatakenaka R, Mitsuoka A, et al.  Development of a new surgical procedure for repairing tracheobronchomalacia. J Thorac Cardiovasc Surg. 1990;100:587–594
  2. Yokomise H, Inui K, Wada H, Goh T, Yagi K, Hitomi S, et al.  High-dose irradiation prevents rejection of canine tracheal allografts. J Thorac Cardiovasc Surg. 1994;107:1391–1397
  3. Yokomise H, Inui K, Wada H, Hasegawa S, Ohno N, Hitomi S. Reliable cryopreservation of trachea for one month in a new trehalose solution. J Thorac Cardiovasc Surg. 1995;110:382–385
  4. Yokomise H, Inui K, Wada H, Ueda M, Hitomi S. Long-term cryopreservation can prevent rejection of canine tracheal allografts with preservation of graft viability. J Thorac Cardiovasc Surg. 1996;111:930–934
  5. Yokomise H, Inui K, Wada H, Ueda M, Hitomi S, Itoh H. Split transplantation of the trachea (a new operative procedure for extended tracheal resection). J Thorac Cardiovasc Surg. 1996;112:314–318
  6. Yamamoto Y, Nakamura T, Shimizu Y, Matsumoto K, Takimoto Y, Liu Y, et al.  Intrathoracic esophageal replacement with a collagen sponge-silicone double layer tube (evaluation of omental-pedicle wrapping and prolonged placement of inner stent). ASAIO J. 2000;46:734–739
  7. Yamamoto Y, Nakamura T, Shimizu Y, Matsumoto K, Takimoto Y, Kiyotani T, et al.  Intrathoracic esophageal replacement in the dog with the use of an artificial esophagus composed of a collagen sponge with a double-layered silicone tube. J Thorac Cardiovasc Surg. 1999;118:276–286
  8. Yamamoto Y, Nakamura T, Shimizu Y, Takimoto Y, Matsumoto K, Kiyotani T, et al.  Experimental replacement of the thoracic esophagus with a bioabsorbable collagen sponge scaffold supported by a silicone stent in dogs. ASAIO J. 1999;45:311–316
  9. Okamoto T, Yamamoto Y, Gotoh M, Liu D, Kihara M, Kameyama K, et al.  Cartilage regeneration using slow release of bone morphogenetic protein (BMP)-2 from a gelatin sponge to treat experimental canine tracheomalacia (a preliminary report). ASAIO J. 2003;49:63–69
  10. Yamamoto M, Tabata Y, Ikada Y. Ectopic bone formation induced by biodegradable hydrogels incorporating bone morphogenetic protein. J Biomater Sci Polym Ed. 1998;9:439–458
  11. Liu D, Maeda M, Okamoto T, Hayashi E, Kameyama K, Sugita A, et al.  Constructive properties of rabbit tracheal cartilage (physical and biochemical changes during development). Jpn J Chest Surg. 1999;13:494–503
  12. Okamoto T, Maeda M, Liu D, Hayashi E, Kameyama K, Sugita A, et al.  The effect of CDDP on constructive properties of rabbit tracheal cartilage. Jpn J Chest Surg. 1999;13:510–518
  13. Funatsu T, Kosaba S, Yagi K, Kuwahara M, Hatakenaka R, Matsubara Y, et al.  Diagnosis and pathogenesis of the acquired tracheobroncho-malacia. Kikanshi Gaku. 1982;4:123–135
  14. Feist JH, Johnson TH, Wilson RJ. Acquired tracheomalacia (etiology and differential diagnosis). Chest. 1975;68:340–345
  15. Shapiro F, Koide S, Glimcher MJ. Cell origin and differentiation in the repair of full-thickness defects of articular cartilage. J Bone Joint Surg Am. 1993;75:532–553
  16. Kawai K, Suzuki S, Tabata Y, Ikada Y, Nishimura Y. Accelerated tissue regeneration through incorporation of basic fibroblast growth factor-impregnated gelatin microspheres into artificial dermis. Biomaterials. 2000;21:489–499
  17. Wang EA, Rosen V, D'Alessandro JS, Bauduy M, Cordes P, Harada T, et al.  Recombinant human bone morphogenetic protein induces bone formation. Proc Natl Acad Sci U S A. 1990;87:2220–2224
  18. Fiorellini JP, Buser D, Riley E, Howell TH. Effect on bone healing of bone morphogenetic protein placed in combination with endosseous implants (a pilot study in beagle dogs). Int J Periodontics Restorative Dent. 2001;21:41–47

PII: S0022-5223(03)01522-8

doi: 10.1016/j.jtcvs.2003.08.017

The Journal of Thoracic and Cardiovascular Surgery
Volume 127, Issue 2 , Pages 329-334 , February 2004

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