The Journal of Thoracic and Cardiovascular Surgery
Volume 126, Issue 1 , Pages 28-38 , July 2003

In vivo gene transfer of pigment epithelium-derived factor inhibits tumor growth in syngeneic murine models of thoracic malignancies

  • Ali Mahtabifard, MD

      Affiliations

    • Thoracic Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center,, New York, NY, USA
    • ,
  • Robert E. Merritt, MD

      Affiliations

    • Department of Cardiothoracic Surgery,, New York, NY, USA
    • ,
  • Reiko E. Yamada, BA

      Affiliations

    • Department of Cardiothoracic Surgery,, New York, NY, USA
    • ,
  • Ronald G. Crystal, MD

      Affiliations

    • Division of Pulmonary and Critical Care Medicine, New York, NY, USA
    • Department of Genetic Medicine, Weill Medical College of Cornell University, New York, NY, USA
    • ,
  • Robert J. Korst, MD

      Affiliations

    • Department of Cardiothoracic Surgery,, New York, NY, USA
    • Department of Genetic Medicine, Weill Medical College of Cornell University, New York, NY, USA
    • Corresponding Author InformationAddress for reprints: Robert J. Korst, MD, Department of Cardiothoracic Surgery, M 404, Weill Medical College of Cornell University, 525 East 68th Street, New York, NY 10021, USA

Received 6 August 2002 ,Revised 12 September 2002 ,Accepted 23 September 2002.

References 

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  4. Tombran-Tink J, Chader GG, Johnson LV. PEDF (a pigment epithelium-derived factor with potent neuronal differentiative activity). Exp Eye Res. 1991;53:411–414
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  11. Raisler BJ, Berns KI, Grant MB, Beliaev D, Hauswirth WW. Adeno-associated virus type-2 expression of pigmented epithelium-derived factor or kringles 1-3 of angiostatin reduce retinal neovascularization. Proc Natl Acad Sci USA. 2002;99:8909–8914
  12. Mori K, Gehlbach P, Yamamoto S, et al.  AAV-mediated gene transfer of pigment epithelium-derived factor inhibits choroidal neovascularization. Invest Opthalmol Vis Sci. 2002;43:1994–2000
  13. Rasmussen H, Chu KW, Campochiaro P, et al.  Clinical protocol. An open-label, phase I, single administration, dose-escalation study of ADGVPEDF.11D (ADPEDF) in neovascular age-related macular degeneration (AMD). Hum Gene Ther. 2001;12:2029–2032
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  15. Rosenfeld MA, Siegfried W, Yoshimura K, et al.  Adenovirus-mediated transfer of a recombinant alpha 1-antitrypsin gene to the lung epithelium in vivo. Science. 1991;252:431–434
  16. Mittereder N, March KL, Trapnell BC. Evaluation of the concentration and bioactivity of adenovirus vectors for gene therapy. J Virol. 1996;70:7498–7509
  17. Hersh JR, Crystal RG, Bewig B. Modulation of gene expression after replication deficient, recombinant adenovirus-mediated gene transfer by the product of a second adenovirus vector. Gene Ther. 1995;2:124–131
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☆ These studies were supported, in part, by Will Rogers Memorial Fund, Los Angeles, Calif, and Gen Vec, Inc, Gaithersburg, Md.

PII: S0022-5223(02)73616-7

doi: 10.1016/S0022-5223(02)73616-7

The Journal of Thoracic and Cardiovascular Surgery
Volume 126, Issue 1 , Pages 28-38 , July 2003

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