The Journal of Thoracic and Cardiovascular Surgery
Volume 125, Issue 1 , Pages 60-70 , January 2003

Baboons undergoing orthotopic concordant cardiac xenotransplantation surviving more than 300 days: Effect of immunosuppressive regimen

Read at the Eightieth Annual Meeting of The American Association for Thoracic Surgery, Toronto, Ontario, Canada, May 1-3, 2000.

Received 4 May 2000 ,Revised 22 August 2002 ,Accepted 9 September 2002.

References 

  1. Alonso de Begona J, Gundry SR, Kawauchi M, et al.  Assessment of baboon lymphocyte subsets and activity in cardiac xenobridging to allotransplantation. Transplant Proc. 1992;24:453–454
  2. Kawauchi M, Gundry SR, Alonso de Begona J, et al.  Prolonged survival of orthotopically transplanted heart xenograft in infant baboons. J Thorac Cardiovasc Surg. 1993;106:779–786
  3. Fukushima N, Fagoaga O, Kawauchi M, et al.  Lymphocyte subset markers as predictors of survival after concordant cardiac xenotransplantation. Transplant Proc. 1994;26:1212–1213
  4. Kawauchi M, Fukushima N, Gundry SR, Alonso de Begona J, Nehlsen-Cannarella S, Bailey LL. Lymphocyte subset monitoring can detect xenoheart rejection in primates. Transplant Proc. 1994;26:1067–1069
  5. Fukushima N, Bouchart F, Gundry SR, et al.  The role of anti-pig antibody in pig-to-baboon cardiac xenotransplant rejection. Transplantation. 1994;57:923–928
  6. Fukushima N, Kawauchi M, Bouchart F, et al.  Graft atherosclerosis in concordant cardiac transplantation. Transplant Proc. 1994;26:1059–1060
  7. Matsumiya G, Gundry SR, Nehlsen-Cannarella S, et al.  Successful long-term concordant xenografts in primates: alteration of the immunoresponse with Mexotrexate. Transplant Proc. 1996;28:751–753
  8. Matsumiya G, Gundry SR, Fukushima N, Kawauchi M, Zuppan CW, Bailey LL. Pediatric cardiac xenograft growth in a rhesus monkey-to-baboon transplantation model. Xenotransplantation. 1996;3:76–80
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  10. Izutani H, Gundry SR, Asano M, Fagoaga O, Zuppan CW, Bailey LL. Probable failure of chimerism induction in orthotopically transplanted monkey hearts in baboons. Transplant Proc. 2000;32:1049–1051
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  15. Kashu Y, Abe Y, Miyauchi K, et al.  The effect of combination splenectomy and low-dose FK506 therapy on graft survival after liver allograft transplantation in rats. Transplantation. 1996;61:1522–1525
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  17. Fujita F, Matai K, Kohno S, Itsubo K. Impact of splenectomy on circulating immunoglobulin levels and the development of postoperative infection following totalgastrectomy for gastric cancer. Br J Surg. 1996;83:1776–1778
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  21. Ko DSC, Bartholomew A, Poncelet AJ, et al.  Demonstration of multilineage chimerism in a nonhuman primate concordant xenograft model. Xenotransplantation. 1998;5:298–304
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  24. Ross HJ, Gullestad L, Pak J, Slauson S, Valantine HA, Hunt SA. Methotrexate or total lymphoid radiation for treatment of persistent or recurrent allograft cellular rejection: a comparative study. J Heart Lung Transplant. 1997;16:179–189
  25. Halperin EC, Bollinger RR. The role of irradiation in solid organ transplantation. Int J Radiat Oncol Biol Phys. 1988;15:979–988
  26. Wecker H, Winn HJ, Auchincloss H. CD4+ T cells, without CD8+ or B lymphocytes, can reject xenogenic skin grafts. Xenotransplantation. 1994;1:8–12
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  28. Yamaoka K, Kim KM, Ishigami T, et al.  Cyclosporin A and FK506 block the negative signaling mediated by surface IgM cross-linking in normal human mature B cells. Immunol Lett. 1993;36:203–208
  29. Goldfeld AE, Flemington EK, Boussiotis VA, et al.  Transcription of the tumor necrosis factor alpha gene is rapidly induced by antiimmunoglobulin and blocked by cyclosporin A and FK506 in human B cells. Proc Natl Acad Sci U S A. 1992;89:12198–12201
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☆ Address for reprints: Steven R. Gundry, MD, Department of Surgery, Loma Linda University Medical School and Medical Center, 11175 Campus St, Suite 21121, Loma Linda, CA 92354 (E-mail: Steven.Gundry@tenethealth.com).

☆☆ 0022-5223/2003 $30.00+0

PII: S0022-5223(02)73336-9

doi: 10.1067/mtc.2003.89

The Journal of Thoracic and Cardiovascular Surgery
Volume 125, Issue 1 , Pages 60-70 , January 2003

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