The Journal of Thoracic and Cardiovascular Surgery
Volume 125, Issue 1 , Pages 30-31 , January 2003

Attenuation of postischemic myocardial injury by cariporide

,Revised 18 April 2002 ,Accepted 10 May 2002.

References 

  1. Karmazyn M, Gan XT, Humphreys RA, Yoshida H, Kusumoto K. The myocardial Na+-H+ exchange: structure, regulation, and its role in heart disease. Circ Res. 1999;85:777–786
  2. Frölich O, Karmazyn M. The Na-H exchanger revisited: an update on Na-H exchange regulation and the role of the exchanger in hypertension and cardiac function in health and disease. Cardiovasc Res. 1997;36:138–148
  3. Piper HM, Balser C, Ladilov YV, Schafer M, Siegmund B, Ruiz-Meana M, et al.  The role of Na+/H+ exchange in ischemia-reperfusion. Basic Res Cardiol. 1996;91:191–202
  4. Gumina RJ, Buerger E, Eickmeier C, Moore J, Daemmgen J, Gross GJ. Inhibition of the Na+/H+ exchanger confers greater cardioprotection against 90 minutes of myocardial ischemia than ischemic preconditioning in dogs. Circulation. 1999;100:2519–2526
  5. Myers ML. Protection of the myocardium with sodium-hydrogen exchange inhibitors: a cardiac surgical perspective. J Thromb Thrombol. 1999;8:53–60
  6. Martin J, Sarai K, Yoshitake M, Haberstroh J, Takahashi N, Lutter G, et al.  Orthotopic transplantation of pig hearts harvested after 30 min of normothermic ischemia: controlled reperfusion with blood cardioplegia containing the Na+-H+-exchange inhibitor HOE 642. Eur J Cardiothorac Surg. 1998;14:607–614
  7. Muraki S, Morris CD, Budde JM, Zhao ZQ, Guyton RA, Vinten-Johansen J. Blood cardioplegia supplemented with the sodium-hydrogen ion exchange inhibitor cariporide attenuates infarct size and coronary artery endothelial dysfunction after severe regional ischemia. J Thorac Cardiovasc Surg. 2002;125:155–164
  8. Vinten-Johansen J, Zhao Z-Q, Sato H. Reduction in surgical ischemic-reperfusion injury with adenosine and nitric oxide therapy. Ann Thorac Surg. 1995;60:852–857
  9. Rupprecht H-J, von Dahl J, Terres W, Melchior Seyfarth K, Richardt G, Schulthei H-P, et al.  Cardioprotective effects of the Na+/H+ exchange inhibitor cariporide in patients with acute anterior myocardial infarction undergoing direct PTCA. Circulation. 2000;101:2902–2908

☆ Address for reprints: Dipak K. Das, PhD, Professor and Director, Cardiovascular Research Center, University of Connecticut, School of Medicine, Farmington, CT 06030-1110 (E-mail: ddas@neuron.uchc.edu).

☆☆ 0022-5223/2003 $30.00+0

PII: S0022-5223(02)73313-8

doi: 10.1067/mtc.2003.66

The Journal of Thoracic and Cardiovascular Surgery
Volume 125, Issue 1 , Pages 30-31 , January 2003

Article Tools