The Journal of Thoracic and Cardiovascular Surgery
Volume 124, Issue 4 , Pages 689-697 , October 2002

The pathology of fresh and cryopreserved homograft heart valves: An analysis of forty explanted homograft valves

Received 1 February 2002 ,Accepted 7 March 2002.

References 

  1. O'Brien MF, Harrocks F, Stafford EG, Gardner MAH, Pohlner PG, Tesar PJ, et al.  The homograft aortic valve: a 29-year, 99.3% follow-up of 1,022 valve replacements. J Heart Valve Dis. 2001;10:334–345
  2. Lund O, Chandrasekaran V, Grocott-Mason R, Elwidaa H, Mazhar R, Kaghaghani A, et al.  Primary aortic valve replacement with allografts over twenty-five years: valve-related and procedure-related determinants of outcome. J Thorac Cardiovasc Surg. 1999;117:77–91
  3. Clarke DR, Campbell DN, Hayward AR. Degeneration of aortic valve allografts in young recipients. J Thorac Cardiovasc Surg. 1993;105:934–942
  4. Hazekamp MG, Koolbergen DR, Braun J, Sugihara H, Cornelisse CJ, Goffin YA, et al.  In situ hybridization: a new technique to determine the origin of fibroblasts in cryopreserved aortic homograft valve explants. J Thorac Cardiovasc Surg. 1995;110:248–257
  5. Koolbergen DR, Hazekamp MG, Kurvers M, de Heer , Cornelisse CJ, Huysmans HA, et al.  Tissue chimerism in cryopreserved homograft valve explants demonstrated by in situ hybridization. Ann Thorac Surg. 1998;66:S225–S232
  6. Hoekstra FME, Knoop CJ, Jutte NHPM, Wassenaar C, Mochtar B, Bos E, et al.  Effect of cryopreservation and HLA-DR matching on the cellular immunogenicity of human cardiac valve allografts. J Heart Lung Transplant. 1994;13:1095–1098
  7. Hoekstra FME, Knoop CJ, Vaessen LMB, Wassenaar C, Jutte NHPM, Bos E, et al.  Donor-specific immune response against human cardiac valve allograft. J Thorac Cardiovasc Surg. 1996;112:281–286
  8. Braun J, Hazekamp MG, Koolbergen DR, Sugihara H, Goffin YA, Huysmans HA, et al.  Identification of host and donor cells in porcine homograft heart valve explants by in situ hybridization. J Pathol. 1997;183:99–104
  9. Pulford KAF, Rigney EM, Micklem KJ, Jones M, Stross WP, Gatter KC, et al.  KP-1: a new monoclonal antibody that detects a monocyte/macrophage associated antigen in routinely processed tissue sections. J Clin Pathol. 1989;42:414–421
  10. Beverly PCL, Callard RE. Distinctive functional characteristics of human T-lymphocytes defined by E rosetting or a monoclonal anti-T cell antibody. Eur J Immunol. 1981;11:329–334
  11. Mitchell RN, Jonas RA, Schoen FJ. Pathology of explanted cryopreserved allograft heart valves: comparison with aortic valves from orthoptic heart transplants. J Thorac Cardiovasc Surg. 1998;115:118–128
  12. Mitchell RN, Jonas RA, Schoen FJ. Structure-function correlations in cryopreserved allograft valves. Ann Thorac Surg. 1995;60:S108–S113
  13. Hilbert SL, Luna RE, Zhang J, Wang Y, Hopkins RA, Yu Z, et al.  Allograft heart valves: the role of apoptosis-mediated cell loss. J Thorac Cardiovasc Surg. 1999;117:454–462
  14. Plissonier D, Henaff M, Poncet P, Paris E, Tron F, Thuillez C. Involvement of antibody-dependent apoptosis in graft rejection. Transplantation. 2000;69:2601–2608
  15. Rajani B, Mee RB, Ratliff NB. Evidence for rejection of homograft cardiac valves in infants. J Thorac Cardiovasc Surg. 1998;115:111–117
  16. Gonzales-Lavin L, Bianchi J, Graf D, Amini S, Gordon GL. Degenerative changes in fresh aortic root homografts in a canine model: Evidence of an immunologic influence. Transplant Proc. 1988;20(Suppl 1):815–819
  17. Salomon RN, Friedman GB, Callow AD, Payne DD, Libby P. Cryopreserved homografts contain viable smooth muscle cells capable of expressing transplantation antigens. J Thorac Cardiovasc Surg. 1993;106:1173–1180
  18. Lupinetti FM, Tsai TT, Kneebone JM, Bove EL. Effect of cryopreservation on the presence of endothelial cells on human valve allografts. J Thorac Cardiovasc Surg. 1993;106:912–917
  19. El Khatib H, Thompson SA, Lupinetti FM. Effect of storage at 4 degrees Celcius in a nutrient medium on antigenic proporties of rat aortic valve allografts. Ann Thorac Surg. 1990;49:792–796
  20. Ross R. Atherosclerosis-an inflammatory disease. N Engl J Med. 1999;340:115–126

 Address for reprints: D. R. Koolbergen, MD, Department of Cardiothoracic Surgery, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands (E-mail: D.R.Koolbergen@lumc.nl).

PII: S0022-5223(02)00140-X

doi: 10.1067/mtc.2002.124514

The Journal of Thoracic and Cardiovascular Surgery
Volume 124, Issue 4 , Pages 689-697 , October 2002