The Journal of Thoracic and Cardiovascular Surgery
Volume 124, Issue 3 , Pages 479-485 , September 2002

The role of oxidative stress in the development of pulmonary arteriovenous malformations after cavopulmonary anastomosis

Read at the Eighty-first Annual Meeting of The American Association for Thoracic Surgery, San Diego, Calif, May 6-9, 2001.

Received 14 May 2001 ,Revised 10 September 2001 ,Accepted 18 September 2001.

References 

  1. Glenn WWL, Patino JF. Circulatory bypass of the right heart. I. Preliminary observations on the direct delivery of the vena caval blood into the pulmonary arterial circulation: azygos vein-pulmonary artery shunt. Yale J Biol Med. 1954;27:147–151
  2. Cloutier A, Ash JM, Smallhorn JF, Williams WG, Trusler GA, Rowe RD, et al.  Abnormal distribution of pulmonary blood flow after the Glenn shunt or Fontan procedure: risk of development of arteriovenous fistulae. Circulation. 1985;72:471–479
  3. Chang RR, Alejos JC, Atkinson D, Jensen R, Drant S, Galindo A, et al.  Bubble contrast echocardiography in detecting pulmonary arteriovenous shunting in children with univentricular heart after cavopulmonary anastomosis. J Am Coll Cardiol. 1999;33:2052–2058
  4. Duncan BW, Kneebone JM, Chi EY, Hraksa V, Isik FF, Rosenthal GL, et al.  A detailed histological analysis of pulmonary arteriovenous malformations in children with cyanotic congenital heart disease. J Thorac Cardiovasc Surg. 1999;117:931–938
  5. Abrams LD. Side-to-side cavopulmonary anastomosis for the palliation of the “primitive ventricle” [abstract]. Br Heart J. 1077;39:926
  6. Malhotra SP, Riemer RK, Thelitz S, He Y, Hanley FL, Reddy VM. Superior cavopulmonary anastomosis suppresses pulmonary angiotensin-converting enzyme activity and expression. J Thorac Cardiovasc Surg. 2001;122:464–469
  7. Semenza GL. HIF-1 and human disease: one highly involved factor. Genes Dev. 2000;14:1983–1991
  8. Semenza GL. Expression of hypoxia-inducible factor 1: mechanisms and consequences. Biochem Pharmacol. 2000;59:47–53
  9. Bernstein HS, Brook MM, Silverman NH, Bristow J. Development of pulmonary arteriovenous fistulae in children after cavopulmonary shunt. Circulation. 1995;92:309–314
  10. Riemer RK, Buscher C, Bansal RK, Black SM, He Y, Natuzzi E. Increased expression of nitric oxide synthase in the myometrium of the pregnant rat uterus. Am J Physiol. 1997;272:E1008–E1015
  11. Srivastava D, Preminger T, Lock JE, Mandell V, Keane JF, Mayer JE, et al.  Hepatic venous blood and the development of pulmonary arteriovenous malformations in congenital heart disease. Circulation. 1995;92:1217–1222
  12. Shah MJ, Rychik J, Fogel MA, Murphy JD, Jacobs ML. Pulmonary AV malformations after cavopulmonary connection: resolution after inclusion of hepatic veins in the pulmonary circulation. Ann Thorac Surg. 1997;63:960–963

☆ Sunil P. Malhorta is a recipient of the National Research Service Award (F32 HL 10339-01) from the National Heart, Lung, and Blood Institute of the National Institutes of Health.

☆☆ Address for reprints: R. Kirk Riemer, PhD, Stanford University, Department of Cardiothoracic Surgery, Falk CVRB-CV116C, Stanford, CA 94305-5407 (E-mail: Riemerk@Stanford.edu).

★ *Present address: Department of Surgery, University of Texas, Houston, Tex.

PII: S0022-5223(02)00109-5

doi: 10.1067/mtc.2002.120346

The Journal of Thoracic and Cardiovascular Surgery
Volume 124, Issue 3 , Pages 479-485 , September 2002

Article Tools

* Image Usage & Resolution