The Journal of Thoracic and Cardiovascular Surgery
Volume 124, Issue 3 , Pages 435-441 , September 2002

The endothelin antagonist BQ123 reduces pulmonary vascular resistance after surgical intervention for congenital heart disease

Received 7 May 2001 ,Revised 28 September 2001 ,Accepted 31 October 2001.

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    Hemodynamic variables during the study protocol. All values are displayed as means ± SEM. Statistical significance of the change of a variable in response to the next study protocol condition is indic

    Hemodynamic variables during the study protocol. All values are displayed as means ± SEM. Statistical significance of the change of a variable in response to the next study protocol condition is indicated as follows: *P < .05 and **P < .01. NS, Not significant; inhNO, inhaled NO.

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    Metabolic variables and derived cardiac output during the study protocol. All values are displayed as means ± SEM. Statistical significance of the change of a variable in response to the next study pr

    Metabolic variables and derived cardiac output during the study protocol. All values are displayed as means ± SEM. Statistical significance of the change of a variable in response to the next study protocol condition is indicated as follows: *P < .05 and **P < .01. NS, Not significant; inhNO, inhaled NO.

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    Vascular resistance during the study protocol. All values are displayed as means ± SEM. Statistical significance of the change of a variable in response to the next study protocol condition is indicat

    Vascular resistance during the study protocol. All values are displayed as means ± SEM. Statistical significance of the change of a variable in response to the next study protocol condition is indicated as follows: *P < .05 and **P < .01. NS, Not significant; inhNO, inhaled NO.

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    Correlation of plasma endothelin levels and PVR response to ETA blockade. The arterial ET-1 concentration is related to the decrease of PVR in response to BQ123 infusion (r2 = 0.89, P < .05).

    Correlation of plasma endothelin levels and PVR response to ETA blockade. The arterial ET-1 concentration is related to the decrease of PVR in response to BQ123 infusion (r2 = 0.89, P < .05).

☆ This work was made possible by a grant from the National Heart Research Fund (No. 99-CC-10), Leeds, United Kingdom.

☆☆ Address for reprints: D. J. Penny, MD, Cardiology Department, Royal Children's Hospital, Flemington Rd, Parkville, Victoria 3052, Australia (E-mail: pennyd@cryptic.rch.unimelb.edu.au).

PII: S0022-5223(02)00104-6

doi: 10.1067/mtc.2002.121492

The Journal of Thoracic and Cardiovascular Surgery
Volume 124, Issue 3 , Pages 435-441 , September 2002

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